韩国人苦味受体TAS2R38遗传变异(rs10246939)、膳食营养摄入和生物临床参数

Benish, Jeong-Hwa Choi
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摘要

与苦味受体基因味觉2受体成员38 (TAS2R38)基因多态性相关的不同苦味感知可能影响个体的食物偏好、营养消耗,并最终影响慢性营养相关疾病,包括心血管疾病。因此,遗传变异对营养摄入和临床指标的影响需要进一步阐明,以促进健康和疾病预防。在这项研究中,我们进行了性别分层分析,以检验遗传变异TAS2R38 rs10246939 A > G与韩国成年人(男性= 1311,女性= 2191)每日营养摄入量、血压和脂质参数之间的关系。我们使用了来自多农村社区队列、韩国基因组和流行病学研究的数据。结果表明,遗传变异TAS2R38 rs10246939与女性膳食中钙(调整p = 0.007)、磷(调整p = 0.016)、钾(调整p = 0.022)、维生素C(调整p = 0.009)和维生素E(调整p = 0.005)等微量营养素的摄入有关。然而,这种基因变异不影响血糖、血脂参数和其他血压指标。这些可能表明这种遗传变异与营养摄入有关,但尚未发现其临床效果。TAS2R38基因型是否可能通过调节饮食摄入成为代谢性疾病风险的潜在预测标志物,还需要更多的研究来探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans.

Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.

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