辅助放疗在胃癌中的作用。

IF 3.2 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Gastric Cancer Pub Date : 2023-01-01 DOI:10.5230/jgc.2023.23.e1
Jeong Il Yu
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引用次数: 0

摘要

虽然通过早期筛查、早期诊断、早期治疗以及手术和辅助化疗的积极应用,局部胃癌的治疗效果不断改善,但是否需要辅助放疗仍存在争议。本综述基于最近发表的两项随机III期研究(胃癌辅助放化疗2和胃癌诱导化疗后放化疗)的结果,以及对包括这两项研究在内的6项随机试验的荟萃分析,评估和讨论了辅助放疗在胃癌中的作用,特别是在行根治性胃切除术合并D2淋巴结切除术的患者中。本文还报道了目前临床情况和未来研究中辅助RT可能的适应症,以便根据复发风险进行个体化治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Role of Adjuvant Radiotherapy in Gastric Cancer.

Although continuous improvement in the treatment outcome of localized gastric cancer has been achieved through early screening, diagnosis, and treatment and the active application of surgery and adjuvant chemotherapy, the necessity of adjuvant radiotherapy (RT) remains controversial. In this review, based on the results of two recently published randomized phase III studies (Adjuvant Chemoradiation Therapy In Stomach Cancer 2 and ChemoRadiotherapy after Induction chemoTherapy of Cancer in the Stomach) and a meta-analysis of six randomized trials including these two studies, the role of adjuvant RT in gastric cancer was evaluated and discussed, especially in patients who underwent curative gastrectomy with D2 lymphadenectomy. This article also reported the possible indications for adjuvant RT in the current clinical situation and in future research to enable patient-specific treatments according to the risk of recurrence.

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来源期刊
Journal of Gastric Cancer
Journal of Gastric Cancer Biochemistry, Genetics and Molecular Biology-Cancer Research
CiteScore
4.30
自引率
12.00%
发文量
36
期刊介绍: The Journal of Gastric Cancer (J Gastric Cancer) is an international peer-reviewed journal. Each issue carries high quality clinical and translational researches on gastric neoplasms. Editorial Board of J Gastric Cancer publishes original articles on pathophysiology, molecular oncology, diagnosis, treatment, and prevention of gastric cancer as well as articles on dietary control and improving the quality of life for gastric cancer patients. J Gastric Cancer includes case reports, review articles, how I do it articles, editorials, and letters to the editor.
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