鸢尾素通过促进SIRT1、AMPK、自噬和端粒酶来延长寿命。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2022-12-12 DOI:10.1017/erm.2022.41
Begoña Sánchez, Mario F Muñoz-Pinto, Mercedes Cano
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引用次数: 4

摘要

衰老的特点是随着时间的推移,分子和细胞的损伤不断累积,导致身体和精神能力的下降。目前,社会预期寿命迅速增加,这导致与年龄有关的疾病增加。因此,研究衰老过程以保证生命最后阶段的最佳状态是至关重要的。近年来,人们对一种名为鸢尾素的肌肉因子的兴趣有所增加,鸢尾素是在体育锻炼中分泌的。这种多肽激素由各种器官产生,主要是肌肉,一旦它被释放到血液中,它就会发挥各种各样的功能,这些功能涉及代谢控制,并可能与一些与衰老相关的疾病有关。本文就鸢尾素的表达机制、血液释放、分布、组织靶点、参与各种细胞代谢反应以及与单磷酸腺苷活化蛋白激酶、沉默信息调节因子t1、自噬和端粒酶等关键抗衰老途径的关系等方面的研究进展进行综述。综上所述,鸢尾素在衰老过程中起着关键作用,它可能是一种新的靶向分子,用于促进长寿途径的治疗方法。然而,要使用这种有前途的激素来获得这种好处,还需要更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase.

Ageing is characterised by the accumulation of molecular and cellular damage through time, leading to a decline in physical and mental abilities. Currently, society has experienced a rapid increase in life expectancy, which has led to an increase in age-associated diseases. Therefore, it is crucial to study the process of ageing to guarantee the best conditions in the final stages of life. In recent years, interest has increased in a myokine known as irisin, which is secreted during physical exercise. This polypeptide hormone is produced by various organs, mainly muscle, and once it is released into the blood, it performs a wide variety of functions that are involved in metabolic control and may be relevant during some of the diseases associated with ageing. The aim of this review is to highlight the recent studies of irisin, such as its mechanism of expression, blood release, distribution, tissue target and participation in various cellular metabolic reactions and the relationship with key anti-ageing pathways such as adenosine monophosphate-activated protein kinase, silent information regulator T 1, autophagy and telomerase. In conclusion, irisin is a key player during the ageing process and it could be a novel target molecule for the therapeutic approach to boost longevity pathways. However, more research will be necessary to use this promising hormone for this gain.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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