脂质控制与铁下垂:从概念到机制。

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Annual review of biochemistry Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI:10.1146/annurev-biochem-052521-033527
Zhipeng Li, Mike Lange, Scott J Dixon, James A Olzmann
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引用次数: 0

摘要

细胞质量控制系统感知和介导稳态反应,以防止异常大分子的积累,这些异常大分子是由生物合成过程中的错误、环境损害或酶和代谢活动的不平衡引起的。脂质是结构多样的大分子,具有许多重要的细胞功能,从膜的结构作用到信号和能量储存分子。与其他大分子一样,脂质会被破坏(如氧化),细胞需要质量控制系统来确保无功能和潜在毒性的脂质不会积聚。铁死亡是一种细胞死亡形式,由脂质控制失败和氧化损伤磷脂的积累引起。在这篇综述中,我们描述了一个脂质控制的框架,以铁下沉为例,强调与脂质损伤、膜重塑以及通过先发制人和损伤修复脂质控制途径抑制或解毒脂质损伤相关的概念。预计《生物化学年度评论》第93卷的最终在线出版日期是2024年6月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
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Lipid Quality Control and Ferroptosis: From Concept to Mechanism.

Cellular quality control systems sense and mediate homeostatic responses to prevent the buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage by environmental insults, or imbalances in enzymatic and metabolic activity. Lipids are structurally diverse macromolecules that have many important cellular functions, ranging from structural roles in membranes to functions as signaling and energy-storage molecules. As with other macromolecules, lipids can be damaged (e.g., oxidized), and cells require quality control systems to ensure that nonfunctional and potentially toxic lipids do not accumulate. Ferroptosis is a form of cell death that results from the failure of lipid quality control and the consequent accumulation of oxidatively damaged phospholipids. In this review, we describe a framework for lipid quality control, using ferroptosis as an illustrative example to highlight concepts related to lipid damage, membrane remodeling, and suppression or detoxification of lipid damage via preemptive and damage-repair lipid quality control pathways.

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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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