低强度噪声暴露可通过提高直流神经网络的兴奋性来增强听觉响度和时序处理。

IF 3 4区 医学 Q2 NEUROSCIENCES Neural Plasticity Pub Date : 2022-11-21 eCollection Date: 2022-01-01 DOI:10.1155/2022/6463355
Lin Shi, Katie Palmer, Haolin Wang, Matthew A Xu-Friedman, Wei Sun
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引用次数: 0

摘要

声音刺激通常用于治疗耳鸣和听力减退。最近的研究发现,长期暴露于噪声环境中会改变中枢听觉系统的突触和发射特性,这将通过声惊跳反射检测到。然而,长期暴露于低强度的声音所产生的感知后果尚不明确。本研究将检测中等强度的噪音暴露(83 dB SPL)对听觉响度的影响,并使用 CBA/CaJ 小鼠对时间处理进行评估。C-Fos 染色用于检测中央听觉通路的神经活动变化。在暴露于 83 dB SPL 噪声(每天 8 小时)两周后,没有发现听性脑干反应(ABR)的持续阈值移动。另一方面,暴露于噪声环境会显著增强声学惊吓反应(ASR)和间隙诱导的前脉冲抑制(gap-PPI)。研究结果表明,低水平的噪音暴露会改变颞叶的敏锐度。噪声暴露会增加耳蜗背核(DCN)和尾部桥脑网状核(PnC)中的c-Fos标记神经元数量,但听觉中枢神经核中的c-Fos标记神经元数量不会增加。我们的研究结果表明,噪声刺激可能通过提高听觉脑干神经元的兴奋性来改变声音的时间处理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN.

Sound stimulation is generally used for tinnitus and hyperacusis treatment. Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level noise exposure (83 dB SPL) on auditory loudness, and temporal processing was evaluated using CBA/CaJ mice. C-Fos staining was used to detect neural activity changes in the central auditory pathway. With two weeks of 83 dB SPL noise exposure (8 hours per day), no persistent threshold shift of the auditory brainstem response (ABR) was identified. On the other hand, noise exposure enhanced the acoustic startle response (ASR) and gap-induced prepulse inhibition significantly (gap-PPI). Low-level noise exposure, according to the findings, can alter temporal acuity. Noise exposure increased the number of c-Fos labeled neurons in the dorsal cochlear nucleus (DCN) and caudal pontine reticular nucleus (PnC) but not at a higher level in the central auditory nuclei. Our results suggested that noise stimulation can change acoustical temporal processing presumably by increasing the excitability of auditory brainstem neurons.

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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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