坚固的纳米颗粒衍生的有色抗生素膜涂层,用于难以涂覆复杂几何形状的医疗设备

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY ACS Nanoscience Au Pub Date : 2022-10-28 DOI:10.1021/acsnanoscienceau.2c00040
Hossein Yazdani-Ahmadabadi, Kai Yu, Sara Khoddami, Demian F. Felix, Han H. Yeh, Haiming D. Luo, Igor Moskalev, Qiong Wang, Rizhi Wang, Dana Grecov, Ladan Fazli, Dirk Lange* and Jayachandran N. Kizhakkedathu*, 
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引用次数: 3

摘要

一个主要的医疗器械相关并发症是植入后与生物膜相关的感染。防止这种情况的一个有希望的方法是用有效的抗菌膜材料覆盖已经商业化的医疗设备。然而,在非平面几何形状的设备上开发一种坚固的高性能抗生物膜涂层仍然没有得到满足。在这里,我们报道了一种易于扩展的基于纳米颗粒的抗生物膜-银复合涂层的开发,该涂层具有长期活性,几乎适用于任何物体,包括使用邻苯二酚有机-水混合物难以涂覆的商业医疗设备。使用筛选方法,我们已经确定了一种有机-水缓冲混合物的组合,它改变了聚乙醇胺的合成、纳米颗粒的形成和稳定性,导致在超高分子量亲水性聚合物存在下原位形成的复合银纳米颗粒在不同物体上的受控沉积,而不管其几何形状和化学性质如何。甲醇介导的聚合物-银复合纳米颗粒的合成产生了一种生物相容的润滑涂层,具有高机械耐久性、长期银释放(~90天)、完全抑制细菌粘附以及长期对各种细菌的优异杀灭活性。涂层导管即使在暴露于苛刻的机械挑战(摩擦、扭曲和拉伸)和储存条件(在水中搅拌>;3个月)后仍保持其优异的活性。我们在体内分别使用经皮导管感染小鼠和皮下植入大鼠模型证实了其对难杀细菌(奇异变形杆菌)的优异杀菌效果(>;99.999%)和高生物相容性。所开发的涂层方法开辟了一条新的途径,将临床使用的医疗设备(如导尿管)转变为高度抗感染的设备,以预防和治疗植入物/设备相关感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Robust Nanoparticle-Derived Lubricious Antibiofilm Coating for Difficult-to-Coat Medical Devices with Intricate Geometry

A major medical device-associated complication is the biofilm-related infection post-implantation. One promising approach to prevent this is to coat already commercialized medical devices with effective antibiofilm materials. However, developing a robust high-performance antibiofilm coating on devices with a nonflat geometry remains unmet. Here, we report the development of a facile scalable nanoparticle-based antibiofilm silver composite coating with long-term activity applicable to virtually any objects including difficult-to-coat commercially available medical devices utilizing a catecholic organic–aqueous mixture. Using a screening approach, we have identified a combination of the organic–aqueous buffer mixture which alters polycatecholamine synthesis, nanoparticle formation, and stabilization, resulting in controlled deposition of in situ formed composite silver nanoparticles in the presence of an ultra-high-molecular-weight hydrophilic polymer on diverse objects irrespective of its geometry and chemistry. Methanol-mediated synthesis of polymer–silver composite nanoparticles resulted in a biocompatible lubricious coating with high mechanical durability, long-term silver release (∼90 days), complete inhibition of bacterial adhesion, and excellent killing activity against a diverse range of bacteria over the long term. Coated catheters retained their excellent activity even after exposure to harsh mechanical challenges (rubbing, twisting, and stretching) and storage conditions (>3 months stirring in water). We confirmed its excellent bacteria-killing efficacy (>99.999%) against difficult-to-kill bacteria (Proteus mirabilis) and high biocompatibility using percutaneous catheter infection mice and subcutaneous implant rat models, respectively, in vivo. The developed coating approach opens a new avenue to transform clinically used medical devices (e.g., urinary catheters) to highly infection-resistant devices to prevent and treat implant/device-associated infections.

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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
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0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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