{"title":"SMC 复合物对染色体 DNA 的组织作用","authors":"Stanislau Yatskevich, James Rhodes, Kim Nasmyth","doi":"10.1146/annurev-genet-112618-043633","DOIUrl":null,"url":null,"abstract":"<p><p>Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases.</p>","PeriodicalId":8035,"journal":{"name":"Annual review of genetics","volume":"53 ","pages":"445-482"},"PeriodicalIF":8.7000,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Organization of Chromosomal DNA by SMC Complexes.\",\"authors\":\"Stanislau Yatskevich, James Rhodes, Kim Nasmyth\",\"doi\":\"10.1146/annurev-genet-112618-043633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases.</p>\",\"PeriodicalId\":8035,\"journal\":{\"name\":\"Annual review of genetics\",\"volume\":\"53 \",\"pages\":\"445-482\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2019-12-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual review of genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-genet-112618-043633\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/10/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-genet-112618-043633","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/10/2 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
摘要
染色体结构维持（SMC）复合体是所有生命体染色体结构的关键组织者。尽管染色体分离、染色体维持、姐妹染色单体内聚和有丝分裂染色体压实等功能看似各不相同，但这些复合体似乎是通过高度保守的机制发挥作用的，它们代表了一类新型 DNA 易位酶。
Structural maintenance of chromosomes (SMC) complexes are key organizers of chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such as chromosome segregation, chromosome maintenance, sister chromatid cohesion, and mitotic chromosome compaction, it appears that these complexes function via highly conserved mechanisms and that they represent a novel class of DNA translocases.
期刊介绍：
The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.
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