{"title":"全切除与部分切除的meta分析:哪个是治疗动静脉透析移植物感染的更好选择?","authors":"Thawatchai Tullavardhana, Anuwat Chartkitchareon","doi":"10.5144/0256-4947.2022.343","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Arteriovenous graft infection (AVGI) is a major cause of hemodialysis access failure. Delayed diagnosis and inappropriate treatment may lead to increased morbidity (3-35%) and mortality up to 12%.</p><p><strong>Objectives: </strong>Compare the postoperative outcomes of total graft excision (TGE) and partial graft excision (PGE) in the treatment of AVGI.</p><p><strong>Designs: </strong>Systematic review and meta-analysis METHODS: The dataset was defined by searching PubMed, EMBASE, Google Scholar, and the Cochrane database for articles outlining the terms arteriovenous graft infection, infected dialysis graft, TGE and PGE published between 1995-2020. The data analysis evaluated the outcomes of TGE and PGE in the management of AVGI. The meta-analysis was performed using Review Manager Software version 5.4.1.</p><p><strong>Main outcome measures: </strong>30-day mortality, recurrent infection, and reoperation rate.</p><p><strong>Sample size: </strong>Eight studies, including 555 AVGI, and 528 patients.</p><p><strong>Results: </strong>PGE showed a significant increase in recurrent graft infection rate (OR=0.23,95% CI=0.13-0.41, <i>P</i><.00001) and re-operation rate for control of infection (OR=0.14,95% CI=0.03-0.58, <i>P</i><.007). However, the 30-day mortality rate did not differ significantly between the groups (OR=0.92,95% CI=0.39-2.17, <i>P</i>=.85).</p><p><strong>Conclusions: </strong>TGE remains a safe and effective surgical method for the management of AVGI. PGE is associated with a higher risk of graft infection and need for re-operation. As a result, PGE should only be considered in carefully selected patients.</p><p><strong>Limitation: </strong>Risk of bias due to the differences in patient characteristics.</p><p><strong>Conflict of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":"42 5","pages":"343-350"},"PeriodicalIF":1.5000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/29/0256-4947.2022.343.PMC9557782.pdf","citationCount":"3","resultStr":"{\"title\":\"Meta-analysis of total versus partial graft excision: Which is the better choice to manage arteriovenous dialysis graft infection?\",\"authors\":\"Thawatchai Tullavardhana, Anuwat Chartkitchareon\",\"doi\":\"10.5144/0256-4947.2022.343\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Arteriovenous graft infection (AVGI) is a major cause of hemodialysis access failure. Delayed diagnosis and inappropriate treatment may lead to increased morbidity (3-35%) and mortality up to 12%.</p><p><strong>Objectives: </strong>Compare the postoperative outcomes of total graft excision (TGE) and partial graft excision (PGE) in the treatment of AVGI.</p><p><strong>Designs: </strong>Systematic review and meta-analysis METHODS: The dataset was defined by searching PubMed, EMBASE, Google Scholar, and the Cochrane database for articles outlining the terms arteriovenous graft infection, infected dialysis graft, TGE and PGE published between 1995-2020. The data analysis evaluated the outcomes of TGE and PGE in the management of AVGI. The meta-analysis was performed using Review Manager Software version 5.4.1.</p><p><strong>Main outcome measures: </strong>30-day mortality, recurrent infection, and reoperation rate.</p><p><strong>Sample size: </strong>Eight studies, including 555 AVGI, and 528 patients.</p><p><strong>Results: </strong>PGE showed a significant increase in recurrent graft infection rate (OR=0.23,95% CI=0.13-0.41, <i>P</i><.00001) and re-operation rate for control of infection (OR=0.14,95% CI=0.03-0.58, <i>P</i><.007). However, the 30-day mortality rate did not differ significantly between the groups (OR=0.92,95% CI=0.39-2.17, <i>P</i>=.85).</p><p><strong>Conclusions: </strong>TGE remains a safe and effective surgical method for the management of AVGI. PGE is associated with a higher risk of graft infection and need for re-operation. As a result, PGE should only be considered in carefully selected patients.</p><p><strong>Limitation: </strong>Risk of bias due to the differences in patient characteristics.</p><p><strong>Conflict of interest: </strong>None.</p>\",\"PeriodicalId\":8016,\"journal\":{\"name\":\"Annals of Saudi Medicine\",\"volume\":\"42 5\",\"pages\":\"343-350\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/29/0256-4947.2022.343.PMC9557782.pdf\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Saudi Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5144/0256-4947.2022.343\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Saudi Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5144/0256-4947.2022.343","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Meta-analysis of total versus partial graft excision: Which is the better choice to manage arteriovenous dialysis graft infection?
Background: Arteriovenous graft infection (AVGI) is a major cause of hemodialysis access failure. Delayed diagnosis and inappropriate treatment may lead to increased morbidity (3-35%) and mortality up to 12%.
Objectives: Compare the postoperative outcomes of total graft excision (TGE) and partial graft excision (PGE) in the treatment of AVGI.
Designs: Systematic review and meta-analysis METHODS: The dataset was defined by searching PubMed, EMBASE, Google Scholar, and the Cochrane database for articles outlining the terms arteriovenous graft infection, infected dialysis graft, TGE and PGE published between 1995-2020. The data analysis evaluated the outcomes of TGE and PGE in the management of AVGI. The meta-analysis was performed using Review Manager Software version 5.4.1.
Main outcome measures: 30-day mortality, recurrent infection, and reoperation rate.
Sample size: Eight studies, including 555 AVGI, and 528 patients.
Results: PGE showed a significant increase in recurrent graft infection rate (OR=0.23,95% CI=0.13-0.41, P<.00001) and re-operation rate for control of infection (OR=0.14,95% CI=0.03-0.58, P<.007). However, the 30-day mortality rate did not differ significantly between the groups (OR=0.92,95% CI=0.39-2.17, P=.85).
Conclusions: TGE remains a safe and effective surgical method for the management of AVGI. PGE is associated with a higher risk of graft infection and need for re-operation. As a result, PGE should only be considered in carefully selected patients.
Limitation: Risk of bias due to the differences in patient characteristics.
期刊介绍：
The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
