{"title":"68Ga-DOTA-TATE 生产过程中的个人剂量当量 Hp(0.07)。","authors":"M Wrzesień, Ł Albiniak","doi":"10.1007/s00411-022-01015-y","DOIUrl":null,"url":null,"abstract":"<p><p>This work presents the exposure of hands of the personnel of a nuclear medicine department who prepare and administer <sup>68</sup>Ga-DOTA-TATE. Dosimetry measurements were performed during three 1-week sessions, for nine production procedures. A total of 360 measurements were made by using high-sensitivity MCP-N thermoluminescent detectors. Annealed detectors were and vacuum-packed in foil and then placed on each fingertip of both hands of five radiochemists and four nurses (one detector for one fingertip). The greatest exposure to ionizing radiation was found on the non-dominant left hand of radiochemists and nurses. A maximum H<sub>p</sub>(0.07)/A value of 49.36 ± 4.95 mSv/GBq was registered for radiochemists during the <sup>68</sup> Ga-DOTA-DATE activity dispensing procedure. For nurses performing the radiopharmaceutical injection procedure, a corresponding maximum value of 1.28 ± 0.13 mSv/GBq was measured, while the mean value for all the nurses was 0.38 mSv/GBq. The dispensing procedure accounted for approximately 60% of the total exposure of radiochemists' fingertips. Based on the results obtained it is recommended that a ring dosimeter should be routinely placed on the middle finger of the non-dominant hand of radiochemists and nurses. Furthermore, it is proposed to systematically train workers in handling open sources of ionizing radiation, with the aim of reducing the required handling time.</p>","PeriodicalId":21002,"journal":{"name":"Radiation and Environmental Biophysics","volume":"62 1","pages":"117-129"},"PeriodicalIF":1.5000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950246/pdf/","citationCount":"0","resultStr":"{\"title\":\"Personal dose equivalent H<sub>p</sub>(0.07) during <sup>68</sup>Ga-DOTA-TATE production procedures.\",\"authors\":\"M Wrzesień, Ł Albiniak\",\"doi\":\"10.1007/s00411-022-01015-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This work presents the exposure of hands of the personnel of a nuclear medicine department who prepare and administer <sup>68</sup>Ga-DOTA-TATE. Dosimetry measurements were performed during three 1-week sessions, for nine production procedures. A total of 360 measurements were made by using high-sensitivity MCP-N thermoluminescent detectors. Annealed detectors were and vacuum-packed in foil and then placed on each fingertip of both hands of five radiochemists and four nurses (one detector for one fingertip). The greatest exposure to ionizing radiation was found on the non-dominant left hand of radiochemists and nurses. A maximum H<sub>p</sub>(0.07)/A value of 49.36 ± 4.95 mSv/GBq was registered for radiochemists during the <sup>68</sup> Ga-DOTA-DATE activity dispensing procedure. For nurses performing the radiopharmaceutical injection procedure, a corresponding maximum value of 1.28 ± 0.13 mSv/GBq was measured, while the mean value for all the nurses was 0.38 mSv/GBq. The dispensing procedure accounted for approximately 60% of the total exposure of radiochemists' fingertips. Based on the results obtained it is recommended that a ring dosimeter should be routinely placed on the middle finger of the non-dominant hand of radiochemists and nurses. Furthermore, it is proposed to systematically train workers in handling open sources of ionizing radiation, with the aim of reducing the required handling time.</p>\",\"PeriodicalId\":21002,\"journal\":{\"name\":\"Radiation and Environmental Biophysics\",\"volume\":\"62 1\",\"pages\":\"117-129\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9950246/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiation and Environmental Biophysics\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1007/s00411-022-01015-y\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation and Environmental Biophysics","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1007/s00411-022-01015-y","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOLOGY","Score":null,"Total":0}
Personal dose equivalent Hp(0.07) during 68Ga-DOTA-TATE production procedures.
This work presents the exposure of hands of the personnel of a nuclear medicine department who prepare and administer 68Ga-DOTA-TATE. Dosimetry measurements were performed during three 1-week sessions, for nine production procedures. A total of 360 measurements were made by using high-sensitivity MCP-N thermoluminescent detectors. Annealed detectors were and vacuum-packed in foil and then placed on each fingertip of both hands of five radiochemists and four nurses (one detector for one fingertip). The greatest exposure to ionizing radiation was found on the non-dominant left hand of radiochemists and nurses. A maximum Hp(0.07)/A value of 49.36 ± 4.95 mSv/GBq was registered for radiochemists during the 68 Ga-DOTA-DATE activity dispensing procedure. For nurses performing the radiopharmaceutical injection procedure, a corresponding maximum value of 1.28 ± 0.13 mSv/GBq was measured, while the mean value for all the nurses was 0.38 mSv/GBq. The dispensing procedure accounted for approximately 60% of the total exposure of radiochemists' fingertips. Based on the results obtained it is recommended that a ring dosimeter should be routinely placed on the middle finger of the non-dominant hand of radiochemists and nurses. Furthermore, it is proposed to systematically train workers in handling open sources of ionizing radiation, with the aim of reducing the required handling time.
期刊介绍:
This journal is devoted to fundamental and applied issues in radiation research and biophysics. The topics may include:
Biophysics of ionizing radiation: radiation physics and chemistry, radiation dosimetry, radiobiology, radioecology, biophysical foundations of medical applications of radiation, and radiation protection.
Biological effects of radiation: experimental or theoretical work on molecular or cellular effects; relevance of biological effects for risk assessment; biological effects of medical applications of radiation; relevance of radiation for biosphere and in space; modelling of ecosystems; modelling of transport processes of substances in biotic systems.
Risk assessment: epidemiological studies of cancer and non-cancer effects; quantification of risk including exposures to radiation and confounding factors
Contributions to these topics may include theoretical-mathematical and experimental material, as well as description of new techniques relevant for the study of these issues. They can range from complex radiobiological phenomena to issues in health physics and environmental protection.