NAD+、Sirtuins和PARPs:增强卵母细胞发育能力。

IF 1.9 4区 生物学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Reproduction and Development Pub Date : 2022-12-19 DOI:10.1262/jrd.2022-052
Charley-Lea Pollard, Zamira Gibb, Aleona Swegen, Christopher G Grupen
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引用次数: 4

摘要

卵母细胞质量是女性生育能力的限制因素。众所周知,产妇营养在生殖功能中起着重要作用,在过去,操纵营养以提高牲畜的生育力是一种常见的做法,特别是在牛的负能量平衡方面。烟酰胺腺嘌呤二核苷酸(NAD+)产生的缺乏与人类和小鼠流产和先天性缺陷的发生率增加有关,而在老年受试者中通过膳食补充提高NAD+可改善卵母细胞质量和胚胎发育。NAD+被细胞内的Sirtuins和多adp核糖聚合酶(parp)消耗,因此需要不断补充以维持各种细胞功能。Sirtuins和PARPs在卵母细胞成熟和胚胎发育中起着重要作用,它们的激活可能对体外胚胎生产和牲畜育种计划有益。本文综述了NAD+、Sirtuins和PARPs在生育方面的作用,为提高NAD+在牲畜育种和胚胎生产计划中的潜在应用提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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NAD+, Sirtuins and PARPs: enhancing oocyte developmental competence.

Oocyte quality is the limiting factor in female fertility. It is well known that maternal nutrition plays a role in reproductive function, and manipulating nutrition to improve fertility in livestock has been common practice in the past, particularly with respect to negative energy balance in cattle. A deficiency in nicotinamide adenine dinucleotide (NAD+) production has been associated with increased incidences of miscarriage and congenital defects in humans and mice, while elevating NAD+ through dietary supplements in aged subjects improved oocyte quality and embryo development. NAD+ is consumed by Sirtuins and poly-ADP-ribose polymerases (PARPs) within the cell and thus need constant replenishment in order to maintain various cellular functions. Sirtuins and PARPs play important roles in oocyte maturation and embryo development, and their activation may prove beneficial to in vitro embryo production and livestock breeding programs. This review examines the roles of NAD+, Sirtuins and PARPs in aspects of fertility, providing insights into the potential use of NAD+-elevating treatments in livestock breeding and embryo production programs.

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来源期刊
Journal of Reproduction and Development
Journal of Reproduction and Development 生物-奶制品与动物科学
CiteScore
3.70
自引率
11.10%
发文量
52
审稿时长
2 months
期刊介绍: Journal of Reproduction and Development (JRD) is the official journal of the Society for Reproduction and Development, published bimonthly, and welcomes original articles. JRD provides free full-text access of all the published articles on the web. The functions of the journal are managed by Editorial Board Members, such as the Editor-in-Chief, Co-Editor-inChief, Managing Editors and Editors. All manuscripts are peer-reviewed critically by two or more reviewers. Acceptance is based on scientific content and presentation of the materials. The Editors select reviewers and correspond with authors. Final decisions about acceptance or rejection of manuscripts are made by the Editor-in-Chief and Co-Editor-in-Chief.
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