[使用 LC-MS/MS 对畜产品中兽药进行改进的多残留分析方法的单实验室验证研究和监测]。

IF 0.2 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Food Hygiene and Safety Science Pub Date : 2023-01-01 DOI:10.3358/shokueishi.64.53
Momoka Hayashi, Maki Kanda, Souichi Yoshikawa, Takayuki Nakajima, Hiroshi Hayashi, Yoko Matsushima, Yumi Ohba, Hiroshi Koike, Chieko Nagano, Kenji Otsuka, Takeo Sasamoto
{"title":"[使用 LC-MS/MS 对畜产品中兽药进行改进的多残留分析方法的单实验室验证研究和监测]。","authors":"Momoka Hayashi, Maki Kanda, Souichi Yoshikawa, Takayuki Nakajima, Hiroshi Hayashi, Yoko Matsushima, Yumi Ohba, Hiroshi Koike, Chieko Nagano, Kenji Otsuka, Takeo Sasamoto","doi":"10.3358/shokueishi.64.53","DOIUrl":null,"url":null,"abstract":"<p><p>A method for the rapid analysis of multiclass residual veterinary drugs in poultry muscle, egg, and raw milk was validated in accordance with Japanese guidelines. Using LC-MS/MS, 20 veterinary drugs, including sulfonamides, coccidiostats, and macrolides were analyzed in one injection. Analytes were extracted from the samples with acetonitrile and then dehydrated and salted out using magnesium sulfate, trisodium citrate, and sodium chloride. This method was assessed by performing recovery tests of chicken muscle, duck muscle, egg, and raw milk spiked with 20 new target analytes at concentrations of 10 and 100 µg/kg. According to this method, 17 out of 20 target analytes satisfied the guideline criteria in chicken muscle and duck muscle, and all 20 target analytes met the criteria in egg and raw milk. The limit of quantification was less than MRLs for all analytes. Residues were detected in 4 out of 99 samples and analyzed using the validated method, finding that the levels of all residues were lower than the limits of quantification. These results suggest that continuous monitoring for a new trend of veterinary drugs is necessary.</p>","PeriodicalId":54373,"journal":{"name":"Food Hygiene and Safety Science","volume":"64 1","pages":"53-60"},"PeriodicalIF":0.2000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Single-laboratory Validation Study and Surveillance Using an Improved Multiresidue Analytical Method for Veterinary Drugs in Livestock Products by LC-MS/MS].\",\"authors\":\"Momoka Hayashi, Maki Kanda, Souichi Yoshikawa, Takayuki Nakajima, Hiroshi Hayashi, Yoko Matsushima, Yumi Ohba, Hiroshi Koike, Chieko Nagano, Kenji Otsuka, Takeo Sasamoto\",\"doi\":\"10.3358/shokueishi.64.53\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A method for the rapid analysis of multiclass residual veterinary drugs in poultry muscle, egg, and raw milk was validated in accordance with Japanese guidelines. Using LC-MS/MS, 20 veterinary drugs, including sulfonamides, coccidiostats, and macrolides were analyzed in one injection. Analytes were extracted from the samples with acetonitrile and then dehydrated and salted out using magnesium sulfate, trisodium citrate, and sodium chloride. This method was assessed by performing recovery tests of chicken muscle, duck muscle, egg, and raw milk spiked with 20 new target analytes at concentrations of 10 and 100 µg/kg. According to this method, 17 out of 20 target analytes satisfied the guideline criteria in chicken muscle and duck muscle, and all 20 target analytes met the criteria in egg and raw milk. The limit of quantification was less than MRLs for all analytes. Residues were detected in 4 out of 99 samples and analyzed using the validated method, finding that the levels of all residues were lower than the limits of quantification. These results suggest that continuous monitoring for a new trend of veterinary drugs is necessary.</p>\",\"PeriodicalId\":54373,\"journal\":{\"name\":\"Food Hygiene and Safety Science\",\"volume\":\"64 1\",\"pages\":\"53-60\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Hygiene and Safety Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3358/shokueishi.64.53\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Hygiene and Safety Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3358/shokueishi.64.53","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

根据日本的指导原则,对快速分析家禽肌肉、鸡蛋和生奶中多类残留兽药的方法进行了验证。使用 LC-MS/MS 一次进样分析了 20 种兽药,包括磺胺类药物、球虫类药物和大环内酯类药物。用乙腈提取样品中的分析物,然后用硫酸镁、柠檬酸三钠和氯化钠进行脱水和盐析。在鸡肉、鸭肉、鸡蛋和生奶中添加浓度为 10 微克/千克和 100 微克/千克的 20 种新目标分析物,对该方法进行了回收测试评估。根据该方法,20 种目标分析物中有 17 种在鸡肉和鸭肉中符合指导标准,所有 20 种目标分析物在鸡蛋和生奶中均符合标准。所有分析物的定量限均低于最高残留限量。在 99 个样本中,有 4 个样本检测到了残留物,并使用验证方法进行了分析,结果发现所有残留物的含量都低于定量限。这些结果表明,有必要对兽药的新趋势进行持续监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[Single-laboratory Validation Study and Surveillance Using an Improved Multiresidue Analytical Method for Veterinary Drugs in Livestock Products by LC-MS/MS].

A method for the rapid analysis of multiclass residual veterinary drugs in poultry muscle, egg, and raw milk was validated in accordance with Japanese guidelines. Using LC-MS/MS, 20 veterinary drugs, including sulfonamides, coccidiostats, and macrolides were analyzed in one injection. Analytes were extracted from the samples with acetonitrile and then dehydrated and salted out using magnesium sulfate, trisodium citrate, and sodium chloride. This method was assessed by performing recovery tests of chicken muscle, duck muscle, egg, and raw milk spiked with 20 new target analytes at concentrations of 10 and 100 µg/kg. According to this method, 17 out of 20 target analytes satisfied the guideline criteria in chicken muscle and duck muscle, and all 20 target analytes met the criteria in egg and raw milk. The limit of quantification was less than MRLs for all analytes. Residues were detected in 4 out of 99 samples and analyzed using the validated method, finding that the levels of all residues were lower than the limits of quantification. These results suggest that continuous monitoring for a new trend of veterinary drugs is necessary.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Food Hygiene and Safety Science
Food Hygiene and Safety Science Medicine-Public Health, Environmental and Occupational Health
CiteScore
0.70
自引率
0.00%
发文量
28
审稿时长
18-36 weeks
期刊介绍: Information not localized
期刊最新文献
[Analytical Method for Melengestrol Acetate in Livestock Products Using LC-MS/MS]. [Establishment of Rapid Simultaneous Analysis Method for Plant Toxins by LC-TOF-MS]. [Implementation and Evaluation of Risk Communication Regarding Residual Pesticides]. [Improved Indophenol Titration Method for Ascorbic Acid Using a Dropper and Electronic Balance: Enhanced Convenience and Efficiency]. [Comparison of DNA Extraction Methods for Processed Foods Containing Soybean or Maize].
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1