耐特比萘芬日本分离株吲哚毛癣菌和红毛癣菌体外唑类药敏试验。

IF 1.4 Q4 MYCOLOGY Medical mycology journal Pub Date : 2023-01-01 DOI:10.3314/mmj.22-00021

Junichiro Hiruma, Utako Kimura, Hiromitsu Noguchi, Masataro Hiruma, Kazutoshi Harada, Rui Kano

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引用次数: 0

摘要

在日本已分离到多株抗真菌菌株indodoineae和rubrum毛癣菌。本研究检测了特比萘芬(TRBF)耐药的印多菌(T. indoinineae)和红菌(T. rubrum)对依非康唑(EFCZ)和吕立康唑(LUCZ)的体外敏感性。所有菌株的最低抑菌浓度分别为:TRBF≥32 mg/l，伊曲康唑< 0.03 ~ 16 mg/l，拉乌康唑< 0.03 ~ 16 mg/l, LUCZ < 0.03 ~ 0.5 mg/l, EFCZ < 0.03 ~ 4 mg/l。值得注意的是，与其他分离株不同，rubrum T. NUBS21012和indottineae T. NUBS 19006T对LUCZ和/或EFCZ具有抗性。

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In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum.

Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF) -resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006^T showed resistance to LUCZ and/or EFCZ unlike the other isolates.

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来源期刊

Medical mycology journal Medicine-Infectious Diseases

CiteScore

1.80

自引率

10.00%

发文量

期刊介绍： The Medical Mycology Journal is published by and is the official organ of the Japanese Society for Medical Mycology. The Journal publishes original papers, reviews, and brief reports on topics related to medical and veterinary mycology.