白塞病患者心血管疾病的危险因素

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2023-01-01 DOI:10.1016/j.jtauto.2023.100195
Yuqian Wang, Sheng Li, Shunli Tang, Xiaoxuan Cai, Juan Bai, Qingmiao Sun, Jianjun Qiao, Hong Fang
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引用次数: 1

摘要

目的白塞氏病(BD)是一种多系统炎症性血管炎,合并心血管疾病可危及生命。本研究的目的是确定与心血管疾病相关的潜在危险因素。方法我们回顾了单一中心的医学数据库。所有双相障碍患者均符合1990年国际研究组标准或白塞病国际标准。记录心血管受累情况、临床表现、实验室特征和治疗情况。分析了参数与心血管受累的关系。结果纳入111例BD患者:21例(18.9%)有心血管受累(CV BD组),99例(81.1%)无心血管受累(非CV BD组)。与非CV型BD患者相比,CV型BD患者中男性和吸烟者的比例显著增加(p = 0.024和p <分别为0.001)。活性部分凝血活素时间(APTT)、心肌肌钙蛋白I和c反应蛋白水平在CV BD组显著升高(p = 0.001、p = 0.031和p = 0.034)。在多变量分析中,心血管疾病与吸烟状态、丘疹病变的存在和较高的APTT相关(p = 0.029, p = 0.021和p = 0.006)。ROC曲线显示APTT可预测心血管受累风险(p <0.01),临界值为33.15 s,敏感性为57.1%,特异性为82.2%。结论BD患者心血管疾病累及与性别、吸烟状况、丘疹病变及APTT升高有关。所有新诊断为双相障碍的患者都应系统地筛查心血管疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Risk factors of cardiovascular involvement in patients with Behcet's disease

Objectives

Behcet's disease (BD) is a multi-systemic inflammatory vasculitis which may be life-threatening if combined with cardiovascular problems. The aim of the study was to identify potential risk factors associated with cardiovascular involvement in BD.

Methods

We reviewed the medical databases of a single center. All BD patients identified as fulfilling the 1990 International Study Group criteria or the International Criteria for Behcet's Disease criteria. Cardiovascular involvement, clinical manifestations, laboratory features, and treatments were recorded. The relationship between parameters and cardiovascular involvement was analyzed.

Results

111 BD patients were included: 21 (18.9%) had documented cardiovascular involvement (CV BD group) and 99 (81.1%) had no cardiovascular involvement (non-CV BD group). Compared with non-CV BD, the proportion of males and smokers were significantly increased in CV BD (p = 0.024 and p < 0.001, respectively). Levels of activated partial thromboplastin time (APTT), cardiac troponin I and C-reactive protein were significantly higher (p = 0.001, p = 0.031, and p = 0.034, respectively) in the CV BD group. Cardiovascular involvement was associated with smoking state, the presence of papulopustular lesions, and higher APTT in multivariate analyzed (p = 0.029, p = 0.021, and p = 0.006, respectively). The ROC curve showed that APTT predicts the risk of cardiovascular involvement (p < 0.01) at a cut-off value of 33.15 s with a sensitivity of 57.1% and specificity of 82.2%.

Conclusion

Cardiovascular involvement in BD patients was associated with gender, smoking state, the presence of papulopustular lesions, and higher APTT. All patients newly diagnosed with BD should be systematically screened for cardiovascular involvement.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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