Željka Babić, Sarah Hallmann, Martin S Havmose, Jeanne D Johansen, Swen M John, Cara Symanzik, Wolfgang Uter, Patricia Weinert, Henk F van der Molen, Sanja Kezic, Jelena Macan, Rajka Turk
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引用次数: 0
摘要
本系统综述根据PRISMA指南进行,重点关注氧化染发剂前体的遗传毒性。在Medline、Web of Science、Cochrane registry、欧盟委员会消费者安全科学委员会和德国MAK委员会的意见中检索了2000年至2021年发表的原始论文。9篇关于对苯二胺(PPD)和甲苯-2,5-二胺(对甲苯二胺)遗传毒性的出版物;包括PTD),报告了17项检测的结果,涵盖了主要的遗传毒性终点。PPD和PTD在体外细菌突变试验中呈阳性,PPD在体内鼠猪体细胞突变试验中也呈阳性。体外染色体畸变试验显示PPD和PTD的致裂性。体外碱性彗星试验显示PPD暴露后DNA损伤,这在体内未得到证实,其中PTD显示出阳性结果。PPD在体外诱导微核形成,并在体内高剂量口服暴露后增加小鼠红细胞微核频率。基于传统遗传毒性试验电池有限数量数据的结果,本系统综述表明染发剂前体PPD和PTD的遗传毒性潜力,这可能对消费者,特别是专业美发师提出重要的健康问题。
Genotoxicity of oxidative hair dye precursors: A systematic review.
This systematic review, conducted according to the PRISMA guidelines, focuses on genotoxicity of oxidative hair dye precursors. The search for original papers published from 2000 to 2021 was performed in Medline, Web of Science, Cochrane registry, Scientific Committee on Consumer Safety of the European Commission and German MAK Commission opinions. Nine publications on genotoxicity of p-phenylenediamine (PPD) and toluene-2,5-diamine (p-toluylenediamine; PTD) were included, reporting results of 17 assays covering main genotoxicity endpoints. PPD and PTD were positive in bacterial mutation invitro assay, and PPD tested positive also for somatic cell mutations in the Rodent Pig-a assay invivo. Clastogenicity of PPD and PTD was revealed by invitro chromosomal aberration assay. The alkaline comet assay invitro showed DNA damage after PPD exposure, which was not confirmed invivo, where PTD exhibited positive results. PPD induced micronucleus formation invitro, and increased micronucleus frequencies in mice erythrocytes following high dose oral exposure invivo. Based on the results of a limited number of data from the classical genotoxicity assay battery, this systematic review indicates genotoxic potential of hair dye precursors PPD and PTD, which may present an important health concern for consumers and in particular for professional hairdressers.
期刊介绍:
Human and Experimental Toxicology (HET), an international peer reviewed journal, is dedicated to publishing preclinical and clinical original research papers and in-depth reviews that comprehensively cover studies of functional, biochemical and structural disorders in toxicology. The principal aim of the HET is to publish timely high impact hypothesis driven scholarly work with an international scope. The journal publishes on: Structural, functional, biochemical, and molecular effects of toxic agents; Studies that address mechanisms/modes of toxicity; Safety evaluation of novel chemical, biotechnologically-derived products, and nanomaterials for human health assessment including statistical and mechanism-based approaches; Novel methods or approaches to research on animal and human tissues (medical and veterinary patients) investigating functional, biochemical and structural disorder; in vitro techniques, particularly those supporting alternative methods