骨髓造血活性中的线粒体转移。

IF 2.3 Q4 CELL & TISSUE ENGINEERING Current Stem Cell Reports Pub Date : 2021-03-01 DOI:10.1007/s40778-020-00185-z
Abhishek K Singh, Jose A Cancelas
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引用次数: 2

摘要

综述目的:造血干细胞(HSC)和骨髓(BM)微环境之间建立了良好的串扰关系,这对于造血紧急情况下的稳态和造血再生至关重要。近十年来,细胞质和细胞器在细胞间的传递所介导的细胞间通讯可以使受损细胞再生和/或修复。线粒体最近被认为是造血干细胞命运的潜在调节因子。本文旨在讨论线粒体动力学的最新进展,特别是线粒体转移在维持HSC活性中的作用,并在干细胞移植和再生医学中具有明确的意义。最近研究发现:HSC的线粒体代谢具有高度异质性,其静止和效力取决于线粒体动力学状态和受损线粒体的清除。最近的证据表明,在应激反应中,BM间质细胞将健康的线粒体转移到HSC,促进HSC生物能量向氧化磷酸化转变,随后刺激白细胞扩张。此外,线粒体从造血干细胞转移到骨髓基质细胞后的代谢重连接可能会修复受损的骨髓生态位,并在清髓后加速限制造血干细胞移植。
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Mitochondria Transfer in Bone Marrow Hematopoietic Activity.

Purpose of review: The well-established crosstalk between hematopoietic stem cells (HSC) and bone marrow (BM) microenvironment is critical for the homeostasis and hematopoietic regeneration in response to blood formation emergencies. Past decade has witnessed that the intercellular communication mediated by the transfer of cytoplasmic material and organelles between cells can regenerate and/or repair the damaged cells. Mitochondria have recently emerged as a potential regulator of HSC fate. This review intends to discuss recent advances in the understanding of the mitochondrial dynamics, specifically focused on the role of mitochondrial transfer, in the maintenance of HSC activity with clear implications in stem cell transplantation and regenerative medicine.

Recent findings: HSC are highly heterogeneous in their mitochondrial metabolism, and the quiescence and potency of HSC depend on the status of mitochondrial dynamics and the clearance of damaged mitochondria. Recent evidence has shown that in stress response, BM stromal cells transfer healthy mitochondria to HSC, facilitate HSC bioenergetics shift towards oxidative phosphorylation, and subsequently stimulate leukocyte expansion. Furthermore, metabolic rewiring following mitochondria transfer from HSPC to BM stromal cells likely to repair the damaged BM niche and accelerate limiting HSC transplantation post myeloablative conditioning.

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来源期刊
Current Stem Cell Reports
Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
0.00%
发文量
19
期刊介绍: The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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