{"title":"激活血浆无活性肾素的内源性蛋白酶。","authors":"B J Leckie","doi":"10.1042/cs055133s","DOIUrl":null,"url":null,"abstract":"<p><p>1. The protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the activation of plasma inactive renin by acid. 2. N-Ethylmaleimide inhibited acid-activation to some extent but o-phenathroline had no effect. 3. Acid-activation of the inactive renin in human plasma is mediated by a serine protease.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"133s-134s"},"PeriodicalIF":0.0000,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055133s","citationCount":"11","resultStr":"{\"title\":\"An endogenous protease activating plasma inactive renin.\",\"authors\":\"B J Leckie\",\"doi\":\"10.1042/cs055133s\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>1. The protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the activation of plasma inactive renin by acid. 2. N-Ethylmaleimide inhibited acid-activation to some extent but o-phenathroline had no effect. 3. Acid-activation of the inactive renin in human plasma is mediated by a serine protease.</p>\",\"PeriodicalId\":10672,\"journal\":{\"name\":\"Clinical science and molecular medicine. Supplement\",\"volume\":\"4 \",\"pages\":\"133s-134s\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1042/cs055133s\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical science and molecular medicine. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1042/cs055133s\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical science and molecular medicine. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1042/cs055133s","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
摘要
1. 蛋白酶抑制剂Trasylol和大豆胰蛋白酶抑制剂阻止了酸对血浆失活肾素的激活。2. n -乙基马来酰亚胺对酸活化有一定的抑制作用，邻苯萘罗林没有作用。3.人血浆中失活肾素的酸活化是由丝氨酸蛋白酶介导的。
An endogenous protease activating plasma inactive renin.
1. The protease inhibitors Trasylol and soyabean trypsin inhibitor prevented the activation of plasma inactive renin by acid. 2. N-Ethylmaleimide inhibited acid-activation to some extent but o-phenathroline had no effect. 3. Acid-activation of the inactive renin in human plasma is mediated by a serine protease.
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