{"title":"淋巴细胞。函数。免疫反应中的遗传限制。","authors":"A J McMichael","doi":"10.1136/jcp.s3-13.1.30","DOIUrl":null,"url":null,"abstract":"The aim of this short review is to describe the role of the major histocompatibility complex (MHC) in the regulation of T lymphocyte function.This genetic complex, which includes the immune response (Ir) genes, imposes certain restrictions on the immune system. The clinical relevance of these findings is indicated by the well-known associations between particular HLA antigens and disease susceptibility. An abnormal immune response appears to play a major role in the pathogenesis of many of these diseases.","PeriodicalId":75996,"journal":{"name":"Journal of clinical pathology. Supplement (Royal College of Pathologists)","volume":"13 ","pages":"30-8"},"PeriodicalIF":0.0000,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s3-13.1.30","citationCount":"3","resultStr":"{\"title\":\"Lymphocytes. 1. Function. Genetic restrictions in the immune response.\",\"authors\":\"A J McMichael\",\"doi\":\"10.1136/jcp.s3-13.1.30\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of this short review is to describe the role of the major histocompatibility complex (MHC) in the regulation of T lymphocyte function.This genetic complex, which includes the immune response (Ir) genes, imposes certain restrictions on the immune system. The clinical relevance of these findings is indicated by the well-known associations between particular HLA antigens and disease susceptibility. An abnormal immune response appears to play a major role in the pathogenesis of many of these diseases.\",\"PeriodicalId\":75996,\"journal\":{\"name\":\"Journal of clinical pathology. Supplement (Royal College of Pathologists)\",\"volume\":\"13 \",\"pages\":\"30-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1979-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1136/jcp.s3-13.1.30\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical pathology. Supplement (Royal College of Pathologists)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/jcp.s3-13.1.30\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical pathology. Supplement (Royal College of Pathologists)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/jcp.s3-13.1.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lymphocytes. 1. Function. Genetic restrictions in the immune response.
The aim of this short review is to describe the role of the major histocompatibility complex (MHC) in the regulation of T lymphocyte function.This genetic complex, which includes the immune response (Ir) genes, imposes certain restrictions on the immune system. The clinical relevance of these findings is indicated by the well-known associations between particular HLA antigens and disease susceptibility. An abnormal immune response appears to play a major role in the pathogenesis of many of these diseases.
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