The effect of prebiotics on intestinal digestion of carbohydrates in lead intoxicated rats

It has been shown the lead intoxication of growing rats result in increase the cavity and membrane carbohydrate hydrolysis and glucose absorption from small intestine which leads to hyperglicemiya. The oral treatment of intoxicated rats with inulin or lactulose results in decrease of carbohydrate assimilation in small intestine and content glucose level in blood. The correcting effect of lactulose on normalization of carbohydrate assimilation is more expressed in compare with inulin. So, inulin and/or lactulose take part in improving of adaptation of the carbohydrate assimilation system in the small intestine during intoxication with lead ions in growing rats. This suggests the prospect of their use as physiologically acceptable additives to stabilize carbohydrate digestion and blood glucose levels in lead and, possibly, other heavy metal intoxication in the growing organism.