Effectiveness Of Oral Clonidine As Anxiolytic And For Attenuation Of Haemodynamic Responses To Laryngoscopy And Intubation.

Background – Oral Clonidine premedication for attenuation of haemodynamic response to laryngoscopy and intubation.Methods : 50 Patients of ASA I & II in age group of 20-50 years undergoing elective surgery were included. Patients were randomly categorized to two groups. Group A receiving tab clonidine 4 ug/Kg 90 minutes prior to induction and Group B receiving placebo. .Heart rate and blood pressure were measured and recorded before, immediately after 1 min and then every 5 minutes after intubation until 15 minutes.Results and conclusion – Clonidine decreases anxiety, systolic blood pressure, diastolic blood pressure, mean blood pressure and heart rate at 90 minutes. Clonidine group showed a significant superiority over placebo in the prevention of increase in systolic blood pressure as well as heart rate over the intubation. Clonidine blunts the stress response to laryngoscopy. Preoperative clonidine is also an effective anxiolysis and hence this study suggest that orally administered clonidine in preanaesthetic period provides more haemodynamic stability and attenuates the stress response to laryngoscopy and intubation.