利用Y-STR标记与反向亲子鉴定相结合的遗传谱系学有助于人类身份鉴定和家族搜索调查(案例研究)

Mahalakshmi N
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引用次数: 0

摘要

大规模灾难受害者的个人身份识别是法医DNA分型的能力之一。利用y染色体STR标记进行遗传系谱分析和反向亲子鉴定(RPT)有助于家族查找调查。一架载有指挥官的多尼尔飞机被宣布逾期,一个月后,在海底发现的骨骼残骸进行了DNA分析。这个案件相当具有挑战性,因为骨骼残骸表现出不同的降解速度。骨骼遗骸与来自受害者血亲的参考样本进行了不同的处理,以产生可重复和可分型的淀粉原蛋白、常染色体和Y-STR谱。y染色体分析结合RPT建立了受害者身份,并在家庭搜索调查中取得了丰硕成果。
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Genetic Genealogy Using Y-STR Markers in Conjunction with Reverse Parentage Testing Aid Efforts in Human Identification and Familial Search Investigation (Case Study)
The personal identification of victim of mass disasters is one of the powers of forensic DNA typing. Genetic genealogy using Y-chromosome STR markers and reverse parentage testing (RPT) aid efforts in familial search investigation. A Dornier aircraft with commandants on board was declared overdue and a month later, skeletal remains found under sea, were subjected to DNA analysis. The case was quite challenging as the skeletal remains exhibited different rates of degradation. The skeletal remains along with reference samples from blood relatives of victims were subjected to different protocols to generate reproducible and typeable, amelogenin, autosomal and Y-STR profiles. Y-chromosome analysis in conjunction with RPT led to establishment of victim identity and rendered fruitful results in familial search investigation.
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