体内肿瘤的翻译调控机制。

Advances in pathobiology Pub Date : 1976-01-01

H C Pitot

{"title":"体内肿瘤的翻译调控机制。","authors":"H C Pitot","doi":"","DOIUrl":null,"url":null,"abstract":"It is clear that regulation of genetic expression of cells need not involve alterations of the basic DNA structure. Between the production of messenger RNA and enzyme degradation there are a number of steps, any of which can be modulated by hormones and other factors to yield cellular abnormalities associated with malignancy. It is important to identify the exact step at which a carcinogen operates and to discover how this alteration is transmitted to the progeny of malignant cells.","PeriodicalId":75448,"journal":{"name":"Advances in pathobiology","volume":"2 ","pages":"29-33"},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Translational regulatory mechanisms in neoplasia in vivo.\",\"authors\":\"H C Pitot\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It is clear that regulation of genetic expression of cells need not involve alterations of the basic DNA structure. Between the production of messenger RNA and enzyme degradation there are a number of steps, any of which can be modulated by hormones and other factors to yield cellular abnormalities associated with malignancy. It is important to identify the exact step at which a carcinogen operates and to discover how this alteration is transmitted to the progeny of malignant cells.\",\"PeriodicalId\":75448,\"journal\":{\"name\":\"Advances in pathobiology\",\"volume\":\"2 \",\"pages\":\"29-33\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in pathobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in pathobiology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

很明显，细胞基因表达的调控不需要涉及基本DNA结构的改变。在信使RNA的产生和酶的降解之间有许多步骤，其中任何一个步骤都可以被激素和其他因素调节，从而产生与恶性肿瘤相关的细胞异常。重要的是确定致癌物起作用的确切步骤，并发现这种改变是如何传递给恶性细胞的后代的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Translational regulatory mechanisms in neoplasia in vivo.

It is clear that regulation of genetic expression of cells need not involve alterations of the basic DNA structure. Between the production of messenger RNA and enzyme degradation there are a number of steps, any of which can be modulated by hormones and other factors to yield cellular abnormalities associated with malignancy. It is important to identify the exact step at which a carcinogen operates and to discover how this alteration is transmitted to the progeny of malignant cells.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advances in pathobiology

自引率

0.00%

发文量

期刊最新文献

Chromosome Structure Steroid Hormone Receptors Aging, cancer and cell membranes. Based on a series of lectures presented at the Given Institute of Pathobiology of the University of Colorado in Aspen, Colorado, August 1978. Lifespans of immunohemopoietic stem cell lines. Studies on the biochemistry of the brain during aging.