口服活性血管紧张素转换酶抑制剂对高血压的长期治疗。

H R Brunner, H Gavras, G A Turini, B Waeber, P Cappuis, D N McKinstry
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引用次数: 21

摘要

1. 卡托普利或SQ 14 225,每天口服两次,可降低高血压患者的血压,无论他们的临床诊断如何,即使他们的血浆肾素活性“正常”或低。2. 长期使用卡托普利,无论是单独使用还是与利尿剂联合使用,都为治疗门诊高血压患者提供了一种强有力的新工具。3.肾素系统可能在维持大多数高血压患者的血压中起重要作用。
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Long-term treatment of hypertension in man by an orally active angiotensin-converting enzyme inhibitor.

1. Captopril or SQ 14 225, administered orally twice a day, reduced the blood pressure of hypertensive patients whatever their clinical diagnosis and even when their plasma renin activity was 'normal' or low. 2. Long-term administration of captopril, either alone or together with diuretics, provides a powerful new tool with which to treat ambulatory hypertensive patients. 3. The renin system may play an important role in maintaining blood pressure in a majority of hypertensive patients.

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Proceedings of the Fifth Meeting of the International Society of Hypertension, Paris, 12-14 June 1978. Brain catecholamines and catecholamine-synthesizing enzymes in renovascular hypertension in the rat. Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension. Definitive evidence for renin in rat brain by affinity chromatographic separation from protease. Renal release of active and inactive renin in essential and renovascular hypertension.
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