H R Brunner, H Gavras, G A Turini, B Waeber, P Cappuis, D N McKinstry
{"title":"口服活性血管紧张素转换酶抑制剂对高血压的长期治疗。","authors":"H R Brunner, H Gavras, G A Turini, B Waeber, P Cappuis, D N McKinstry","doi":"10.1042/cs055293s","DOIUrl":null,"url":null,"abstract":"<p><p>1. Captopril or SQ 14 225, administered orally twice a day, reduced the blood pressure of hypertensive patients whatever their clinical diagnosis and even when their plasma renin activity was 'normal' or low. 2. Long-term administration of captopril, either alone or together with diuretics, provides a powerful new tool with which to treat ambulatory hypertensive patients. 3. The renin system may play an important role in maintaining blood pressure in a majority of hypertensive patients.</p>","PeriodicalId":10672,"journal":{"name":"Clinical science and molecular medicine. Supplement","volume":"4 ","pages":"293s-295s"},"PeriodicalIF":0.0000,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/cs055293s","citationCount":"21","resultStr":"{\"title\":\"Long-term treatment of hypertension in man by an orally active angiotensin-converting enzyme inhibitor.\",\"authors\":\"H R Brunner, H Gavras, G A Turini, B Waeber, P Cappuis, D N McKinstry\",\"doi\":\"10.1042/cs055293s\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>1. Captopril or SQ 14 225, administered orally twice a day, reduced the blood pressure of hypertensive patients whatever their clinical diagnosis and even when their plasma renin activity was 'normal' or low. 2. Long-term administration of captopril, either alone or together with diuretics, provides a powerful new tool with which to treat ambulatory hypertensive patients. 3. The renin system may play an important role in maintaining blood pressure in a majority of hypertensive patients.</p>\",\"PeriodicalId\":10672,\"journal\":{\"name\":\"Clinical science and molecular medicine. Supplement\",\"volume\":\"4 \",\"pages\":\"293s-295s\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1042/cs055293s\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical science and molecular medicine. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1042/cs055293s\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical science and molecular medicine. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1042/cs055293s","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Long-term treatment of hypertension in man by an orally active angiotensin-converting enzyme inhibitor.
1. Captopril or SQ 14 225, administered orally twice a day, reduced the blood pressure of hypertensive patients whatever their clinical diagnosis and even when their plasma renin activity was 'normal' or low. 2. Long-term administration of captopril, either alone or together with diuretics, provides a powerful new tool with which to treat ambulatory hypertensive patients. 3. The renin system may play an important role in maintaining blood pressure in a majority of hypertensive patients.