[培养的神经元和神经胶质细胞系中的阿片受体位点]。

Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles Pub Date : 1978-10-30

F Garcin, J Ciesielski-Treska, G Ulrich, J C Louis, P Mandel

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引用次数: 0

摘要

在3个胶质细胞系和2个神经元细胞系中发现了立体特异性饱和高亲和力的3h -纳洛酮结合。结合动力学研究似乎表明在5种细胞系中只有一类受体位点。急性暴露于吗啡(1 × 10(-5)M)与pge1诱导的腺苷酸环化酶刺激并没有导致任何细胞系cAMP水平的降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Opiate receptor sites in neuronal and glial cell lines in culture].

A stereospecific saturable high affinity binding of 3H-naloxone has been found in 3 glial and 2 neuronal cell lines. Kinetic study of binding seems to indicate only one class of receptor sites in the 5 cell lines. Acute exposure to morphine (1 X 10(-5)M) concurrent with PGE1-induced stimulation of adenylate cyclase did not result in a decrease of the cAMP level in any cell line tested.

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Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles

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