某些氨基衍生物解离的速率常数

Anud M. A. Efhema, Ziadan J. Khalaf
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引用次数: 0

摘要

氨基糖苷类衍生物包括新霉素、链霉素、卡那霉素和庆大霉素,用特殊试剂,即苯甲酰氯;苯磺酰氯和邻苯二甲酸酐,以提高HPLC分析的紫外检测能力。但柱前衍生存在许多问题,为了解决这一问题,利用抗生素衍生物的电导率来计算解离常数和水解速率,从而确定关注型反应。此外,还研究了控制抗生素衍生物水解的特性。
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RATE CONSTANT OF SOME AMINO DERIVATIVES DISSOCIATION
Amino glycoside derivation including, Neomycin, Streptomycin, Kanamycin and Gentamycin with special reagents, which are benzoylchloride; benzene sulfonyl chloride and phthalic anhydride were made to enhance Uv-detectability for HPLC analysis. But there are many problems facing pre column derivation and in order to solve this, the conductivity of antibiotic derivatives were used to calculate the dissociation constant and the hydrolysis rate which determined concern type reaction. In addition the characteristics those controlling the hydrolysis of antibiotic-derivatives were investigated.
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