基于ADS1292的自适应深部脑刺激系统

Dechun Zhao, Li Wang, Shanshan Cheng
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引用次数: 2

摘要

为了长期监测帕金森病的发展,研究脑深部刺激对帕金森病的作用机制,设计了基于ADS1292的帕金森大鼠适应性脑深部刺激系统。该系统由主控单元、采集模块、激励模块和无线通信模块组成,系统采用高性能、低功耗的MSP430作为主控芯片。高分辨率、低噪声的模数转换芯片ADS1292采集本地场电位(LFP)信号。刺激模块使用DAC8532输出具有可调幅度、频率和脉宽的方波。同时,无线通信模块通过蓝牙将LFP信号发送给上位机进行处理,并接收上位机的控制命令,实现对刺激参数的自适应调节。通过验证,系统完成了刺激信号的产生和微弱生物电信号的采集。该系统重量轻、体积小、功耗低,非常适合大鼠等小型动物实验。
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Adaptive Deep Brain Stimulation System Based on ADS1292
In order to monitor the development of Parkinson's disease for a long time and to study the mechanism of deep brain stimulation for Parkinson's disease, an adaptive deep brain stimulation system based on ADS1292 was designed for Parkinson's rats. The system consists of a main control unit, an acquisition module, a stimulation module and a wireless communication module, the system uses high-performance, low-power MSP430 as the main control chip. The high resolution, low noise analog to digital conversion chip ADS1292 acquires local field potential (LFP) signals. The stimulus module uses the DAC8532 to output a square wave with adjustable amplitude, frequency, and pulse width. At the same time, the wireless communication module uses the Bluetooth to transmit the LFP signal to the upper computer for processing and receive the control command from the upper computer for achieving adaptive adjustment of the stimulus parameters. Through verification, the system completes the generation of stimulation signals and the acquisition of weak bioelectric signals. The system is light in weight, small in size and low in power consumption, and is very suitable for small animal experiments such as rats.
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