用代理指标解释斯里兰卡COVID-19的Epi曲线

I. Karunathilake, W. Weerasinghe, R. Rupasinghe, MC Weerasinghe
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引用次数: 0

摘要

斯里兰卡早在2020年1月27日确诊首例COVID-19病例之前就采取了措施,除了建立了详细的流行病学监测和传染病控制系统外,还采取了避免COVID-19传入和传播的措施。每日病例数等传统指标已被用作跟踪疫情进展的指标。然而,随着大流行病的持续,人们认为有必要制定代理指标,以便更好地了解其行为和未来趋势。本研究的目的是探索使用代理指标,即观察到的检测阳性率(TPR)和对流行曲线的流动性趋势来解释COVID-19大流行的行为;它们的有用性和局限性。该研究的信息是根据斯里兰卡卫生当局在2021年4月1日至2021年6月30日期间发布并公开提供的COVID-19每日状况报告收集的。定期更新的谷歌社区流动性报告收集了这段时间内流动性变化的趋势。可以看出,每周观察到的TPR所描述的病例“趋势”为决策和评估控制COVID - 19的方法提供了比使用传统代理指标(如每日病例数)更好的信息。由于社区未发现病例、报告不足、报告延迟以及聚合酶链反应积压,报告的病例数可能低于实际数字。流动性变化趋势和观察到的TPR趋势可共同用于监测和评估使用封锁措施控制疾病的有效性。建议在衡量疾病严重程度和评价在资源有限的情况下为经济有效地控制疾病而使用旅行限制的情况时采用这种替代指标。
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Use of Proxy Indicators to Interpret the Epi Curve of COVID-19 in Sri Lanka
Sri Lanka has taken measures to avoid the introduction and spread of COVID-19 well before the country confirmed its first COVID 19 case on 27th January 2020, on top of its detailed epidemiological surveillance and infectious disease control system. Traditional indicators such as the daily case numbers have been used as an indicator to keep track of the outbreak progression. However, as the pandemic continued, the need to have proxy indicators was felt, both to better understand its behavior as well as future trends. The objective of this study was to explore the use of proxy indicators, namely the observed test positivity rate (TPR) and the mobility trends against the epidemic curve to interpret the behavior of the COVID-19 pandemic; their usefulness, and limitations. The information for the study was gathered using the COVID-19 daily status reports published and made publicly available by the Sri Lankan health authorities for the duration of 01/04/2021 to 30/06/2021. Trends of change of mobility during the period are gathered using regularly updated Google Community Mobility Reports. It is seen that the ‘trend’ of cases as depicted by weekly Observed TPR carries better information for decision making and evaluation of the methods to contain COVID 19 than using traditional proxy indicators such as the daily case numbers. The reported numbers in cases can be less than the actual numbers due to non-detection of cases in the community, under-reporting, delays in reporting, and PCR backlog. Trends of mobility changes and the trends of observed TPR together can be used to monitor and evaluate the effectiveness of the use of lockdown measures to contain the disease. It is recommended to adopt the use of such proxy indicators both in measuring the disease severity and the evaluation of the use of travel restrictions to contain the disease cost-effectively in a resource-limited setting.
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