System-based anatomy and physiology

Children who undergo general anaesthesia have an increased perioperative risk of morbidity and mortality compared with adults. This is due to differences in anatomy and reduced physiological reserves. A clear understanding of neonatal and paediatric anatomy and physiology is therefore essential to provide safe paediatric perioperative care. This chapter outlines major anatomical and physiological differences of the paediatric and neonatal airway, including causes and treatment of airway obstruction. Essential aspects of the respiratory, cardiovascular, CNS, and hepatorenal systems are discussed. Important considerations of fluid and thermal control are described that form the basis of safe paediatric anaesthesia practice.