肾母细胞瘤的诊断与治疗

Nicodemus
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引用次数: 0

摘要

肾母细胞瘤是常见于五岁以下儿童的恶性肿瘤之一。这种肿瘤经常被父母或看护者偶然发现,他们注意到孩子腹部有一个肿块。Wilms肿瘤的具体影响因素尚未发现。然而,它通常与特定综合征相关,作为易感因素和特定基因突变。该肿瘤引起的症状多种多样,由于肿瘤向肺部分布,可从无症状到严重症状。通常,肾母细胞瘤侵袭一侧肾脏(单侧),具有不同的分级和特殊的组织学。一般来说,治疗包括手术、化疗和放疗,这取决于肿瘤的级别。患者的治愈率和生存率高,复发率低。因此,对Wilms肿瘤的临床诊断和怀疑成为儿童腹部肿块的诊断之一。
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Diagnosis and Management of Wilms Tumor
Wilms Tumor is one of the malignancies frequently found in children under five years old. This tumor is frequently found coincidentally by parents or caregivers who notice a lump in the children’s abdomen. The specific factors of Wilms tumor have not been detected yet. However, it is often associated with specific syndromes as a predisposing factor and a mutation of specific genes. The symptoms caused by this tumor are varied, starting from asymptomatic without any symptom to severe symptoms due to the tumor distribution to the lung. In general, Wilms tumor attacks one of the kidneys (unilateral) with different grades and particular histology. Generally, the management encompasses surgery, chemotherapy, and radiotherapy, depending on the tumor grade. The patients’ recovery rate and managed survival rate were quite high with a low recurrence rate. Therefore, a clinical approach and skepticism of Wilms tumor become one of the diagnoses in children with an abdominal mass.
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