沙利度胺致感觉轴索多神经病变1例

David Eliécer Rodríguez, Fernando Ortiz, Jefferson Alexander Caleño, Mauro Andres Herrera
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介绍:目前有几种化疗药物可用于各种恶性肿瘤的治疗;然而,许多药物都有副作用。下面描述一例沙利度胺引起的多发性神经病变。病例描述:65岁男性,有继发性骨髓纤维化史,使用沙利度胺治疗,因神经性疼痛和双手感觉异常就诊5个月。体格检查时,他表现为双手感觉减退和痛觉过敏。电诊断结果显示为轴突型感觉多发性神经病。讨论:化疗引起的周围神经病变(CIPN)是发生在高达70%的患者中的副作用。症状包括运动和敏感缺陷。EDX研究证实了诊断和特征。在特殊情况下,沙利度胺主要累及轴突。CIPN没有标准的治疗方法,但有几种药物可以改善症状。结论:CIPN是化疗患者的常见并发症。为了改善病人的功能,理疗师是理想的专业人士,为这个实体提供全面的方法。
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Thalidomide-induced sensory axonal polyneuropathy: A case report
Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many are associated with adverse effects. A case of thalidomide- induced polyneuropathy is described below. Case Description: A 65year old man, with a history of secondary myelofibrosis in management with thalidomide, consulted for 5months of neuropathic pain and paresthesia in both hands. On physical examination, he presented hypoesthesia and hyperalgesia in both hands. In the electrodiagnostic studies (EDX) a sensory polyneuropathy of axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect that occurs in up to 70% of patients. Symptomatology includes motor and sensitive deficit. EDX studies confirm diagnoses and characteristics. For the particular case of thalidomide involvement is mainly axonal. There is no standard treatment for CIPN, but several drugs can improve symptoms. Conclusions: CIPN is a frequent complication in patients managed with chemotherapy. The physiatrist is the ideal professional to provide a comprehensive approach to this entity, in order to improve the patient’s functionality.
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