David Eliécer Rodríguez, Fernando Ortiz, Jefferson Alexander Caleño, Mauro Andres Herrera
{"title":"沙利度胺致感觉轴索多神经病变1例","authors":"David Eliécer Rodríguez, Fernando Ortiz, Jefferson Alexander Caleño, Mauro Andres Herrera","doi":"10.15406/ipmrj.2023.08.00341","DOIUrl":null,"url":null,"abstract":"Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many are associated with adverse effects. A case of thalidomide- induced polyneuropathy is described below. Case Description: A 65year old man, with a history of secondary myelofibrosis in management with thalidomide, consulted for 5months of neuropathic pain and paresthesia in both hands. On physical examination, he presented hypoesthesia and hyperalgesia in both hands. In the electrodiagnostic studies (EDX) a sensory polyneuropathy of axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect that occurs in up to 70% of patients. Symptomatology includes motor and sensitive deficit. EDX studies confirm diagnoses and characteristics. For the particular case of thalidomide involvement is mainly axonal. There is no standard treatment for CIPN, but several drugs can improve symptoms. Conclusions: CIPN is a frequent complication in patients managed with chemotherapy. The physiatrist is the ideal professional to provide a comprehensive approach to this entity, in order to improve the patient’s functionality.","PeriodicalId":336722,"journal":{"name":"International Physical Medicine & Rehabilitation Journal","volume":"147 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thalidomide-induced sensory axonal polyneuropathy: A case report\",\"authors\":\"David Eliécer Rodríguez, Fernando Ortiz, Jefferson Alexander Caleño, Mauro Andres Herrera\",\"doi\":\"10.15406/ipmrj.2023.08.00341\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many are associated with adverse effects. A case of thalidomide- induced polyneuropathy is described below. Case Description: A 65year old man, with a history of secondary myelofibrosis in management with thalidomide, consulted for 5months of neuropathic pain and paresthesia in both hands. On physical examination, he presented hypoesthesia and hyperalgesia in both hands. In the electrodiagnostic studies (EDX) a sensory polyneuropathy of axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect that occurs in up to 70% of patients. Symptomatology includes motor and sensitive deficit. EDX studies confirm diagnoses and characteristics. For the particular case of thalidomide involvement is mainly axonal. There is no standard treatment for CIPN, but several drugs can improve symptoms. Conclusions: CIPN is a frequent complication in patients managed with chemotherapy. The physiatrist is the ideal professional to provide a comprehensive approach to this entity, in order to improve the patient’s functionality.\",\"PeriodicalId\":336722,\"journal\":{\"name\":\"International Physical Medicine & Rehabilitation Journal\",\"volume\":\"147 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Physical Medicine & Rehabilitation Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/ipmrj.2023.08.00341\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Physical Medicine & Rehabilitation Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/ipmrj.2023.08.00341","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Thalidomide-induced sensory axonal polyneuropathy: A case report
Introduction: Several chemotherapeutic agents are currently available for the management of various malignancies; however, many are associated with adverse effects. A case of thalidomide- induced polyneuropathy is described below. Case Description: A 65year old man, with a history of secondary myelofibrosis in management with thalidomide, consulted for 5months of neuropathic pain and paresthesia in both hands. On physical examination, he presented hypoesthesia and hyperalgesia in both hands. In the electrodiagnostic studies (EDX) a sensory polyneuropathy of axonal type was concluded. Discussion: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect that occurs in up to 70% of patients. Symptomatology includes motor and sensitive deficit. EDX studies confirm diagnoses and characteristics. For the particular case of thalidomide involvement is mainly axonal. There is no standard treatment for CIPN, but several drugs can improve symptoms. Conclusions: CIPN is a frequent complication in patients managed with chemotherapy. The physiatrist is the ideal professional to provide a comprehensive approach to this entity, in order to improve the patient’s functionality.