妊娠对5期慢性肾脏疾病患者同种异体敏感化的影响

I. Usmonov
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摘要

本文旨在探讨妊娠对5期慢性肾脏疾病妇女异体免疫的影响,以及异体肾移植的供体选择和免疫抑制问题。分析表明,孕妇的同种异体免疫很常见,但研究仍然很少。研究表明,在怀孕期间促进母胎耐受的内源性机制可能会持续到产后。此外,这种免疫平衡是否可以用于改善移植结果仍有待确定。因此,临床研究人员仍然有很大的机会为这一领域做出贡献,并改善敏感妇女的移植结果。
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Impact of pregnancy on allosensitization in women with stage 5 chronic kidney disease
The article is devoted to the problem of the effect of pregnancy on alloimmunization in women with stage 5 chronic kidney disease and the choice of a donor and immunosuppression for kidney allotransplantation. The analysis showed that alloimmunization of pregnant women is common and remains poorly studied. Studies suggest that endogenous mechanisms contributing to maternal-fetal tolerance during pregnancy may persist in the postpartum period. Moreover, it remains to be determined whether this immunological balance can be used to improve transplant outcomes. Thus, significant opportunities remain for clinical researchers to contribute to this field and improve transplant outcomes for sensitized women. 
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