I. Dontwi, Seth Christopher Yaw Appiah, F. Boateng, S. Asiedu-Addo
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引用次数: 0
摘要
“梅尔波”是动脉血压的长周期振荡(6至12秒),在人类和其他哺乳动物的心血管系统中已经观察和研究了100多年。提出了一个人类心血管系统的数学模型,其中包含了与迈耶波发生有关的参数。利用Lyapunov稳定性和Hopf分岔理论对模型进行了分析。分析表明,控制静脉容积的压反射反馈回路增益的增加可能导致振荡的发生,而其他参数的变化不影响平衡状态的稳定性。在梅尔波振荡周期和年龄依赖性方面,结果与人类受试者的梅尔波观察结果一致。这导致了对其发生的一种解释,即梅尔波是一种“增益诱导的不稳定性”。非洲数学和科学教育研究杂志Vol. 4 2006: pp. 77-91
A Mathematical Model to Investigate Gain-Induced Oscillation in the Human Cardiovascular System
“Mayer waves” are long-period (6 to 12 seconds) oscillations in arterial blood pressure, which have been observed and studied for more than 100 years in the cardiovascular system of humans and other mammals. A mathematical model of the human cardiovascular system is presented, incorporating parameters relevant to the onset of Mayer waves. The model is analyzed using methods of Lyapunov stability and Hopf bifurcation theory. The analysis shows that increase in the gain of the baroreflex feedback loop controlling venous volume may lead to the onset of oscillations, while changes in the other parameters considered do not affect stability of the equilibrium state. The results agree with observations of Mayer waves in human subjects, both in the period of the oscillations and in the observed age-dependence of Mayer waves. This leads to a proposed explanation of their occurrence, namely that Mayer waves are a “gain-induced instability”. African Journal of Educational Studies in Mathematics and Sciences Vol. 4 2006: pp. 77-91