乳腺DCE-MRI放射学特征提取对新辅助化疗期间患者病理变化的响应

Priscilla Dinkar Moyya, Mythili Asaithambi, A. K. Ramaniharan
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引用次数: 3

摘要

乳腺癌疾病是全世界发病率和死亡率的主要原因。动态对比增强磁共振成像(DCE-MRI)是乳腺癌治疗监测中最常用的评估化疗反应的方法。从磁共振图像中获得的放射组学特征在反映肿瘤生物学方面具有潜力。在这项工作中,我们试图探讨乳腺DCE-MRI衍生的放射学特征及其对新辅助化疗(NAC)的反应的临床潜力。本研究使用的数据(10例患者,20项研究(Visit-1和Visit-2))来自公共领域定量成像网络(QIN)乳腺DCE-MRI数据库。利用Mazda软件提取全乳区域放射学特征,量化第一次和第二次访视期间的病理变化。共提取了176个纹理和形状特征,并采用学生t检验进行统计分析。结果表明,放射组学特征能够区分NAC在访视1和访视2期间的肿瘤生物学变化。GeoW2、GeoW3、GeoW4、GeoRs、GeoRc、GeoRm、直方图强度50%百分位、Theta1等特征均具有统计学意义,p值在0.03 ~ 0.08之间。因此,放射学特征可以作为反映NAC病理反应的辅助指标,因此本研究具有临床意义。
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Extraction of Radiomic Features from Breast DCE-MRI Responds to Pathological Changes in Patients During Neoadjuvant Chemotherapy Treatment
Breast cancer disorders are leading cause of morbidity and mortality worldwide. Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) is the most common method of assessing the response to chemotherapy in breast cancer treatment monitoring. Radiomic features obtained from MR images have potential in reflecting the tumor biology. In this work, an attempt has been made to investigate the clinical potential of breast DCE-MRI derived radiomic features and its response to Neoadjuvant Chemotherapy (NAC). The data used in this study (10 Patients with 20 studies (Visit-1 & Visit-2) were obtained from public domain Quantitative Imaging Network (QIN) Breast DCE-MRI database. Using Mazda software, the radiomic features were extracted from whole breast region to quantify the pathological variations during visit-1 and visit-2. Totally, 176 texture and shape features were extracted and analyzed statistically using student's t test. Result shows that, the radiomic features were able to differentiate the variations in the tumor biology during visit-1 and visit-2 due to NAC. The features such as GeoW2, GeoW3, GeoW4, GeoRs, GeoRc, GeoRm, 50 percentile of histogram intensity and Theta1 were found to be statistically significant with p values ranging from 0.03 to 0.08. Hence it appears that, the radiomic features could be used as adjunct measure in reflecting the pathological response during NAC and thus this study seems to be clinically significant.
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