The influence of a permanent Isoproterenol (ISO) application on the dynamics of the Sephadex inflammation

The influence of Isoproterenol on the nmmber of the different types of white blood cells appearing during the course of the Sephadex inflammation was investigated in rats. Isoproterenol treatment causes a decrease of the number of the immigrating neutrophils within the first two days and an increase of the lymphocytes during almost the entire experiment. A sudden decrease of the number of these cell types, indicating a massive cell destruction, was followed by immigration of eosinophilic granulocytes after 24 hrs. Isoproterenol accelerated and augmented this immigration. We conclude, that perishing neutrophils and lymphocytes produce or mediate the production of factors which attract eosinophils and moreover that Isoproterenol enhances the production or the effect of these factors. The mechanism underlying this enhancement is not known. We suppose a specific ß-adrenergic influence, because we could not reproduce this increasing effect with adrenaline.