第4组和第15组以及用于治疗癌症和病毒的有机锡缩合聚合物

C. Carraher, M. Roner, P. Slawek, Francesca Mosca, J. Frank, Lindsey C. Miller
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引用次数: 1

摘要

本文简要介绍了4族茂金属化合物、15族有机金属化合物和有机锡聚合物在治疗人类癌症肿瘤和病毒中的应用。这些含金属聚合物对包括胰腺、肺、脑、乳腺、前列腺和结肠在内的所有主要实体肿瘤都有良好的抑制作用。它们还显示出对多种病毒的抑制作用,包括寨卡病毒、疱疹病毒和牛痘病毒。采用界面聚合和市售反应物可快速合成聚合物。它们为医生提供了一种治疗各种癌症和病毒的新型药物。
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Groups 4 and 15 and Organotin Condensation Polymers for The Treatment of Cancers and Viruses
This short review describes the use of group 4 metallocenes, group 15 organometallics and organotin polymers in the treatment of human cancer tumors and viruses. These metal-containing polymers show good inhibition of all the main group solid tumors including pancreatic, lung, brain, breast, prostate and colon human cell lines. They also show inhibition of a variety of viruses including zika, herpes and vaccinia viruses. Synthesis of the polymers is rapid employing interfacial polymerization and commercially available reactants. They offer physicians a new class of drugs for the treatment of a variety of cancers and viruses.
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