氨基糖苷类药物及其与头孢菌素联合使用的小管毒性作用。

A W Mondorf, J Hendus, J Breier, L Maske, C Bindzi, J E Scherberich, W Schoeppe
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引用次数: 0

摘要

通过尿AAP浓度测量,头孢菌素与氨基糖苷对人肾近端小管膜的作用明显不同。除头孢菌素对近端小管有轻微影响外,头孢菌素对近端小管无影响。相反,在给药三天后,氨基糖苷引起尿中近端小管膜蛋白的累积增加。妥布霉素对正常人肾近端小管刷状边界膜的影响最小,而阿米卡星的影响最大。头孢菌素与氨基糖苷的联合使用增加了对近端小管的潜在毒性作用。
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Tubular-toxic effects of aminoglycosides and their combinations with cephalosporins.

Cephalosporins have a distinctly different effect from that of aminoglycosides on membranes of the proximal tubule of the human kidney as measured by urinary AAP concentrations. Except for a slight influence by cephacetrile, cephalosporins showed no effect on the proximal tubule. In contrast, after three days of administration, the aminoglycosides caused a cumulative increase in membrane proteins of the proximal tubule to be excreted in the urine. Tobramycin appears to have the least and amikacin the greatest effect on the brush border membranes of the proximal tubule of the normal human kidney. The combination of cephalosporins with aminoglycosides increases the potential toxic effect on the proximal tubule.

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