未来用于视网膜植入的NPDA装置的几何优化与仿真

V. M. Moorthy, Viranjay Srivastava Mohan
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摘要

本研究的重点是改进用于视网膜植入的纳米光电二极管阵列(NPDA)视网膜下植入装置的器件结构和电极几何形状,旨在使丧失视力和视敏度(VA)的人恢复视力至优于失明的水平。针对电子器件模拟器,作者提出了一种采用有机纳米材料的高效NPDA器件的结构设计。目前研究人员模拟的NPDA装置嵌入了3600个刺激像素(直径100 μm),分散在5.5 mm的有效半径区域内。通过优化NPDA器件的几何形状,作者证明了每个像素都有可能产生所需的电流和电压,以利用12 mW/mm2的辐照度刺激神经元。在这里,作者专注于提高设备的效率,因为效率的提高往往会导致更多的像素(通过减少电极几何形状而增加电极数量),如果像素的增加会增加视觉感知。因此,从理论上讲,100 μm的锡电极可以恢复高达20/80的VA。这种NPDA植入物有可能将视力加强到高于视力丧失水平的VA水平。
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Geometrical Optimization and Simulation of NPDA Device for Future Use in Retinal Implant
The focus of this research was to improve the device structure and electrode geometry of nanophotodiode array (NPDA) subretinal implant devices for retinal implants, with the aim to restore the sight of people who have lost their vision and visual acuity (VA) to better than blindness level. In light of the electronic device simulator, the authors present a design depicting the configuration of a high-efficiency NPDA device by incorporating organic nanomaterials. The present researchers’ simulated NPDA device embeds 3600 stimulating pixels (100 μm in diameter) dispersed over a 5.5-mm active radius area. By optimizing the NPDA device geometry, authors demonstrated that each pixel has the potential to produce the required electrical current and voltage for neuronal stimulation utilizing an irradiance of 12 mW/mm2. Here, the authors concentrated on increasing the efficiency of the device because the increase in efficiency will tend to result in more pixels (greater number of electrodes by reducing the electrode geometry) if the increase in a pixel increases the visual perception. Therefore, theoretically, the 100-μm Tin electrode can reinstate VA up to 20/80.This NPDA implant has the potential to reinforce vision to a level of VA that is superior to that of the vision loss level.
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