1014补体C3缺乏增加NK细胞抗肿瘤免疫，控制肿瘤生长

Regular and Young Investigator Award Abstracts Pub Date : 2022-11-01 DOI:10.1136/jitc-2022-sitc2022.1014

G. Lal, Pradipta Pal, S. Paul, H. T. Meitei, Praneet Wahi, A. Sahu

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引用次数: 0

摘要

野生型NK细胞。从荷瘤小鼠分离的NK细胞与NK细胞相比，IL-2、IL-15、IL-18对NK细胞具有细胞毒活性，促炎细胞因子如GM-CSF和IFN-g的分泌增加。与同型对照IgG单抗相比，用抗nk1.1单抗消耗-/-小鼠中的NK细胞可显著防止生长减少。

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1014 Complement C3 deficiency increases the anti-tumor immunity of NK cells and controls tumor growth

wild-type NK cells. NK cells isolated from tumor-bearing -/- mice showed cytotoxic activity to the NK cells increased secretion of pro-inflammatory cytokines as GM-CSF and IFN-g when with IL-2, IL-15, IL-18 compared to NK cells. Depleting NK cells in -/- mice with anti-NK1.1 mAb significantly prevented the reduction of growth as compared to isotype control IgG mAb.

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Regular and Young Investigator Award Abstracts

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