Comparison of the effects of remifentanil and dexmedetomidine in patients under general anesthesia for rhinoplasty

Objective We aim to compare the effects of remifentanil and dexmedetomidine administered under general anesthesia in patients undergoing rhinoplasty. The primary outcomes were hemodynamics, postoperative pain, and recovery; the secondary outcomes were PONV, shivering, and patient and surgeon satisfaction. Methods In this randomized controlled, double-blind trial, 62 patients 18–65 years of age and ASA I-II class who underwent rhinoplasty under elective conditions were accepted to the study and divided into two groups. Group R (n = 31) received 0.25 μg/kg/min intravenously infusion during the operation without a loading dose. Group D (n = 31) was initiated with a bolus of 1 μg/kg over 10 min before induction of anesthesia and then received 0.5 μg/kg/h intravenously infusion during the operation. The patient’s pain level was assessed at 5 min, 30 min, and 12 h after surgery. Intraoperative hemodynamics, vital parameters, PONV, shivering, and patient and surgical satisfaction were evaluated. Results Remifentanil and dexmedetomidine had similar effects on hemodynamics and additional analgesic requirements. No postoperative complications, including PONV, occurred in either group. Recovery from anesthesia was faster, and pain scores were lower in the dexmedetomidine group. While patient satisfaction was similar, surgeon satisfaction was higher in the remifentanil group. Conclusion We think dexmedetomidine can be used safely and effectively as an adjuvant during general anesthesia for nasal surgery.