{"title":"药物输注时单室模型血浆药物浓度的数值模拟实时评估","authors":"P. Pal","doi":"10.26782/jmcms.2022.03.00005","DOIUrl":null,"url":null,"abstract":"In the present numerical study, we apply an ODE IVP to plasma drug concentrations for a one-compartment model in presence of drug infusion. Solution procedure is done in a Matlab environment. The outcome shows that the infusion rate at time t = 4 h is discontinuous but the corresponding plasma concentration-time profile looks smooth at that time.","PeriodicalId":254600,"journal":{"name":"JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES","volume":"452 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"NUMERICAL SIMULATION ON-TIME EVALUATION OF PLASMA DRUG CONCENTRATIONS FOR ONE-COMPARTMENT MODEL IN PRESENCE OF DRUG INFUSION\",\"authors\":\"P. Pal\",\"doi\":\"10.26782/jmcms.2022.03.00005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the present numerical study, we apply an ODE IVP to plasma drug concentrations for a one-compartment model in presence of drug infusion. Solution procedure is done in a Matlab environment. The outcome shows that the infusion rate at time t = 4 h is discontinuous but the corresponding plasma concentration-time profile looks smooth at that time.\",\"PeriodicalId\":254600,\"journal\":{\"name\":\"JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES\",\"volume\":\"452 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26782/jmcms.2022.03.00005\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26782/jmcms.2022.03.00005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
NUMERICAL SIMULATION ON-TIME EVALUATION OF PLASMA DRUG CONCENTRATIONS FOR ONE-COMPARTMENT MODEL IN PRESENCE OF DRUG INFUSION
In the present numerical study, we apply an ODE IVP to plasma drug concentrations for a one-compartment model in presence of drug infusion. Solution procedure is done in a Matlab environment. The outcome shows that the infusion rate at time t = 4 h is discontinuous but the corresponding plasma concentration-time profile looks smooth at that time.
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