Evaluation of the effect of vitamin D on the salivary and serum levels of interleukin-8 in patients with periodontitis stage I and II grade A.

Objectives: Evaluate the effect of vitamin D in conjugation with phase 1 periodontal therapy on the GCF, salivary and serum level of IL-8 in periodontitis stage I and II grade A patients. Subjects and Methods: A total of 40 medically healthy adult subjects with periodontitis stage I and II grade A. Twenty patients received a full mouth supra –and sub-gingival scaling and root planning, in addition to vitamin D (one alpha 0.5mcg) one capsules daily for 6 months. Control group: twenty patients received a full mouth supra – and sub-gingival scaling and root planing only. Samples Collection of Gingival Crevice Fluid, blood samples and saliva before treatment and 3 and 6 months after: Clinical evaluation and Serum level of vitamin D, Serum, salivary and GCF levels of IL-8. Results: Study group after treatment for 6 months showed a higher mean vitamin D % increase ( ↑ 117.41 ± 46.82) from baseline than control group ( ↑ 2.77±20.34) The results showed, also,that study group reported a reduction in GCF IL-8 % while control group increased, at both observation period of 3and 6 month. At 3 months, study group showed a reduction in Serum IL-8% from baseline than control group. At 6 months, Study group showed a reduction in Serum IL-8% from baseline while control group increased. There was a negative correlation between vitamin D and IL-8. Conclusion: Vitamin D supplementation may reduce the severity of periodontal disease. Vitamin D may have a potential role in the inhibition of periodontal inflammation by inhibiting the IL-8 expression