中药治疗肝病的计算机网络药理学研究及影像学辅助分析

Yuemei Mao, Chong Luo
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摘要

本文研究了计算机药理学和影像学辅助分析在肝脏疾病治疗中的重要作用。首先,介绍了近年来以虚拟筛选技术、各种组学技术和网络药理学为主要内容的计算机药理学方法及其在中药研究领域的应用;结合研究与实践,运用计算机药理学方法对慢性中药治疗进行分析。综述了肝脏疾病的有效成分及其作用机制的研究进展。结果表明,中药治疗慢性肾脏病的化学成分-靶点相互作用网络与西医治疗慢性肾脏病的化学成分-靶点相互作用网络存在较大差异。
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Computer Network Pharmacology Research and Imaging Assisted Analysis of Traditional Chinese Medicine for the Treatment of Liver Disease
This article studies the important computer pharmacology and imaging assisted analysis for the treatment of liver disease. First, it introduces the computer pharmacology methods with virtual screening technology, various omics technologies and network pharmacology as the main content in recent years and their applications in the field of Chinese medicine research; combined with research and practice, the computer pharmacology method is used to analyze the treatment of chronic Chinese medicine. The progress of the effective components and mechanism of liver disease was reviewed. The results showed that there is a big difference between the chemical component-target interaction network of traditional Chinese medicine for the treatment of chronic kidney disease and the chemical component-target interaction network of western medicine.
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