J Overgaard, O S Nielsen, M Overgaard, S Steenholdt, A Jakobsen, A Sell
{"title":"orgotein在正常和恶性哺乳动物细胞中缺乏辐射防护作用。","authors":"J Overgaard, O S Nielsen, M Overgaard, S Steenholdt, A Jakobsen, A Sell","doi":"10.3109/02841867909128216","DOIUrl":null,"url":null,"abstract":"<p><p>The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.</p>","PeriodicalId":75417,"journal":{"name":"Acta radiologica: oncology, radiation, physics, biology","volume":"18 4","pages":"305-12"},"PeriodicalIF":0.0000,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841867909128216","citationCount":"4","resultStr":"{\"title\":\"Lack of radiation protective effect of orgotein in normal and malignant mammalian cells.\",\"authors\":\"J Overgaard, O S Nielsen, M Overgaard, S Steenholdt, A Jakobsen, A Sell\",\"doi\":\"10.3109/02841867909128216\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.</p>\",\"PeriodicalId\":75417,\"journal\":{\"name\":\"Acta radiologica: oncology, radiation, physics, biology\",\"volume\":\"18 4\",\"pages\":\"305-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1979-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/02841867909128216\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta radiologica: oncology, radiation, physics, biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/02841867909128216\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica: oncology, radiation, physics, biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/02841867909128216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lack of radiation protective effect of orgotein in normal and malignant mammalian cells.
The potential radiation protective effect of orgotein, a metalloprotein with superoxide dismutase activity, was investigated in L1A2 tumour cells in vitro, jejunal crypt cells and C3H mouse mammary carcinoma in vivo. No effect of orgotein, given either 2 hours before irradiation or 30 min after, was observed compared to the effect of irradiation alone. Thus, it was concluded that orgotein did not influence the primary radiation response in air in mammalian cells.
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