细胞松弛素B对TA3肿瘤细胞的体外作用

Beitrage zur Pathologie Pub Date : 1977-10-01 DOI:10.1016/S0005-8165(77)80092-9

W. Ryd , B. Hagmar

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引用次数: 6

摘要

采用显微摄影和扫描电镜观察了细胞松弛素B (Cytochalasin B, CB)对腹水肿瘤TA3的作用。炭黑诱导剂量依赖性和可逆性细胞麻痹。1 μg CB/ml可引起明显但不完全的麻痹。细胞保持其一般形状，但发育出许多水泡。10 μg CB/ml引起细胞完全麻痹，假足和微绒毛收缩。当CB被清除后，细胞迅速恢复原来的形态和活力。回收过程在CB去除后几分钟内开始，几乎在15分钟内完成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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In vitro Effects of Cytochalasin B on TA3 Tumor Cells

We studied the effect of Cytochalasin B (CB) on two lines of the ascites tumor TA3 by microcinematography and scanning electron microscopy.

CB induces a dose dependent and reversible cell paralysis. One μg CB/ml causes a pronounced but incomplete paralysis. The cells retain their general shape but develop numerous blebs. Ten μg CB/ml causes a complete cell paralysis and a retraction of pseudopods and microvilli. When CB is removed, the cells rapidly regain their original form and motility. The recovery process starts within minutes after CB removal and is almost completed in 15 min.

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