Immunocompetent cells in resistance to bacterial infections.

INTRODUCTION .................................... 284 Nonspecific Resistance to Infection .......................................... 284 Specific Resistance to Infection .............................................. 285 CELLS INVOLVED IN HUMORAL ANTIBODY PRODUCTION ............. 285 CELLS INVOLVED IN CELL-MEDIATED IMMUNITY ................. 287 HUMORAL ANTIBODIES IN RESISTANCE TO BACTERIAL INFECTION ... 289 Agglutinins ................................................................. 289 Opsonins .................................................................. 289 Precipitins .................................................................. 290 Bacteriolysins .............................................................. 290 Other Antibacterial Antibodies .............................................. 290 CELL-MEDIATED IMMUNE MECHANISMS IN RESISTANCE TO BACTERIAL INFECTION .............................................................. 291 Migration Inhibition Factor ................................................. 291 Macrophage Chemotactic Factor ............................................. 291 Chemotactic Factor for Leukocytes .......................................... 292 Blastogenic Factor for Lymphocytes ......................................... 292 Transfer Factor ............................................................. 292 BACTERIAL ADJUVANTS ............................... 292 Lipopolysaccharide .......................................................... 292 BordeteUa pertussis .................. ....................................... 293 Mycobacteria and Mycobacterial Components ............... ........... 294 Corynebacterium parvum and Nocardia ....................................... 294 Listeria monocytogenes .................... ........................ 294 Other Bacterial Adjuvants ............................................ 294 ROLE OF MACROPHAGES ............................................ 294 Stimulation of Macrophages by Other Cells and Factors ........ ............... 295 Stimulation of Macrophages by Antibodies ................. .................. 295 Stimulation of Macrophages by Bacteria ..................................... 295 Stimulation of Macrophages by Chemicals ................... ................. 295 Effects of Macrophages and Macrophage Products on Other Cells ..... ......... 296 Macrophage Mediators .................................................... 296 ROLE OF THYMUS-DERIVED CELLS (T CELLS) ........... ................ 296 Stimulation of T Lymphocytes by Antigens ........... ........................ 297 Stimulation of T Lymphocytes by Mitogens ........... ........................ 297 Specificity of Resistance to Bacterial Infections ......... ..................... 297 ROLE OF BONE MARROW-DERIVED CELLS ............. .................. 298 B Cells in Humoral Antibody Production ............. ........................ 298 Bone Marrow-Derived Cells in Cell-Mediated Immunity ....... ................ 298 SUMMARY ........................ ............................ 300 Macrophages ........................................................... 300 T Lymphocytes ............................................................ 300 B Cells ........................................................... 300 LITERATURE CITED .................................................... 300