Identification of Potential Long Non-coding RNA Biomarkers for Breast Cancer Patients with Somatic BRCA1 Mutations from RNA-Seq Datasets

The gene BRCA1 is a human tumor suppressor gene found in all humans, and it was reported that around 5-10% of people with breast cancer have a mutation of their BRCA1 genes. In this study, we investigated potential long non-coding RNA biomarkers for BRCA1 mutation carriers breast cancer cases. From differential expression analysis of RNA-Seq data, we identified 6 significant long non-coding genes (p-value < 0.05). There are three long non-coding genes which were reported as potential biomarkers in breast cancer: AC008268.1, AC091013.1 and AL021395.1. Then the other three genes (AC008592.5, AC090204.1, LINC02570) are novel candidates reported in this study.