避孕套作为避孕手段对衣原体疾病传播效果的数学分析

Akeem O. Yunus, M. A. Omoloye
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引用次数: 0

摘要

由沙眼衣原体引起的衣原体病是全球主要的性传播传染病之一。这种疾病的发展具有致命的影响,累积起来造成数百万人死亡。衣原体引起许多并发症,如女性不孕,慢性盆腔疼痛和炎症。以前的研究没有考虑未被发现的感染者对疾病动态传播的影响。因此,这项工作调查了未被发现的感染个体的影响和避孕套作为一种避孕手段在疾病的动态传播中的功效。利用常微分方程建立了衣原体疾病动态传播的六室模型。人群分为易感个体、暴露个体、感染未发现症状个体、感染已发现症状个体、感染无症状个体和痊愈个体。利用正解技术考察了模型的适定性。采用下一代矩阵法计算基本繁殖数(R0)。利用Lyapunov函数研究了地方性平衡。结果表明,当基本繁殖数小于1时,无病平衡稳定(R0<1)。由于构造的李雅普诺夫函数是负定的,地方性平衡是稳定的。数值分析表明,未被发现的感染个体的增加促进了疾病的传播。研究结果表明,未被发现的感染个体在衣原体疾病的传播中起着至关重要的作用。此外,使用避孕套作为避孕手段减少了疾病的传播。
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Mathematical Analysis of Efficacy of Condom as a Contraceptive on the Transmission of Chlamydia Disease
Chlamydia disease caused by the Chlamydia trachomatis is one of the major sexually transmitted infectious diseases globally. The progression of this disease has deadly effects cumulating into millions of death. Chlamydia causes numerous complications such as infertility in female, chronic pelvic pain and inflammation. Previous studies did not consider the effects of undetected infected individuals on the dynamic spread of the disease. Hence, this work investigated the effects of undetected infected individuals and efficacy of condom as a contraceptive in the dynamic spread of the disease. A six compartmental model to study the dynamic spread of chlamydia disease was developed using system of ordinary differential equation. The population was divided into susceptible, exposed, infected undetected symptomatic, infected detected symptomatic, infected asymptomatic and recovered individuals. The well-posedness of the model was investigated by the positivity of solution technique. Basic reproduction number (R0) was computed using Next Generation Matrix Method. The endemic equilibrium was investigated by the use of Lyapunov function. The results showed that the disease free equilibrium was stable whenever the basic reproduction number is less than unity (R0<1). The endemic equilibrium was found to be stable as a results of constructed Lyapunov function being negative definite. Numerical analysis showed that increasing in the undetected infected individuals enhanced the spread of the disease. Findings showed that undetected infected individuals played a vital role in the spread of Chlamydia disease. Moreover, using condom as a contraceptive reduced the spread of the disease.
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