微通道尺寸对微流式细胞仪三维流体动力聚焦的影响

N. Selamat, Muhammad Syafiq Bin Rahim, A. Ehsan
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引用次数: 1

摘要

流体动力聚焦是微流体细胞分选装置中的一种重要方法。利用COMSOL multiphysics软件进行了流式细胞仪的设计和仿真。该装置能够通过控制两个护套通道的流量Q来创建自对准流。本研究的目的是研究微流式细胞仪中通道尺寸变化对流体流动的影响。采用流量比Qs/Qi,求出鞘层通道与样品通道的最佳流量比值。模拟结果表明,当Qs小于Qi时,流的大小更大,流的长度更长。但是,当Qs等于Qi时,流变小,流的长度变短。同样,当q大于Qi时,流也会变小、变短。结果表明:通道尺寸越大,流体流动越好;
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Effect of microchannel sizes on 3D hydrodynamic focusing of a microflow cytometer
Hydrodynamic focusing is an important method used in microfluidics cell sorting devices. A design of flow cytometer has been developed and simulated using COMSOL Multyphysics software. The device is capable of creating a self-aligned stream by manipulating the flow rate, Q in both sheath channel. The objective of this research is to study the effect of channel size variation on the fluid flow in the micro flow cytometer device. The flow rate ratio Qs/Qi is applied in order find the best flow rate ratio value between sheath channel and sample channel. Simulated results showed that when Qs is smaller than Qi, the stream size is bigger and the length of the stream is longer. However, Qs is equal to Qi, the stream becomes smaller and the length of the stream is shorter. Similary, when Qs is bigger than Qi, the stream becomes smaller and shorter. The results showed that fluid flow is better when the size of the channel is bigger.
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