In-vivo characterization of zebrafish bone degradation and regeneration models by optical coherence tomography

Zebrafish is a well-established in vivo model that exhibit high homology with the development of human innate immunity while well-established human disease model in vivo for various human diseases as well as the drug safetyevaluation process. However, few optical imaging methods could effectively visualize the structure of adult zebrafish due to their limited penetration depth. In this paper, in vivo high-resolution and long-term characterization of human bone disease models based on zebrafish were achieved with optical coherence tomography (OCT). The capability of three-dimensional OCT imaging was also played important role in visualization of zebrafish bone disease model. This paper presents the construction of bone degradation and regeneration model and OCT imaging in vivo based on zebrafish.