逆向排序:建立重叠森林的一种更快的方法

N. Garg, Manubhav Jain, Sugandha Singhania, Parinay Prateek, Prantik Biswas, Indu Chawla
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引用次数: 0

摘要

在分子生物学中,计算反转距离和确定反转序列以转化基因组的问题是推导基因间关系的有力工具。给定两个有符号的排列,我们需要找到最短的反转序列来将一个转换成另一个。最先进的计算反转距离的多项式时间算法是使用由排列形成的重叠图来寻找连接分量,然后识别图结构(如障碍)。先前的研究人员使用了Union-Find结构,即$\mathbf{O}(\mathbf{n}\alpha(\mathbf{n}))$算法($\alpha$->逆Ackerman函数)来确定连接的组件。随后提出了一种线性时间算法来查找连接分量,这是对现有工作的更快实现。该算法应用于有符号排列的无符号扩展。在第一次扫描中,找到断点图中的循环。然后在第二次扫描中,形成一个重叠森林,其中给出了排列的所有连接组件。在本文中,我们通过减少对无符号排列的扫描来优化现有的算法来构建重叠森林。
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Sorting by Reversals: A Faster Approach for Building Overlap Forest
The problem of computing the reversal distance and determining a sequence of reversals to transform a genome in molecular biology is a powerful tool to derive relationships between genes. Given two signed permutations, we need to find the shortest sequence of reversals to transform one into another. The foremost polynomial-time algorithm to calculate the reversal distance used an overlap graph formed from the permutation to find connected components and then identified graph structures like hurdles. Previous researchers have used a Union-Find structure, an $\mathbf{O}(\mathbf{n}\alpha(\mathbf{n}))$ algorithm ($\alpha$->inverse Ackerman function) to determine the connected components. A linear time algorithm for finding the connected components, which was a faster implementation of the existing works was proposed later. This algorithm is applied to an unsigned extension of the signed permutation. In the first scan, cycles in a breakpoint graph were located. Then in a second scan, an overlap forest is formed which gave all the connected components of the permutation. In this paper, we optimize the existing algorithm to construct the overlap forest by reducing a scan of the unsigned permutation.
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