Creatine Kinase-MB and Beta-Hydroxybutyrate Dehydrogenase with Antioxidant Agent in Heart Disease Patients

The research Measures the activity of CK-MB & BHBDH enzymes with some biochemical parameters and TAO for the heart Patients group (147), also to the control group (94). The results showed an increase in activity for both enzyme CKMB (33.29±4.96 U/L) and BHBDH (224.12± 0.82 U/L) in serum for the heart Patients group compared to the control (8.67±0.41 U/L, 136.73±0.95 U/L) respectively. The results also showed a significant difference in the activity of CK-MB and BHBDH in serum for the angina pectoris group with the myocardial infarction group. The results indicated that there was a significant increase activity of peroxidase in serum for the heart Patients group (92.33 ± 4.68 U/L) compared to the control group (47.66± 0.60 U/L), while there was a significant decrease in the activity of Catalase and TAO concentration in serum for heart patients group (25.53 ±0.47 U/L, 0.89 ±0.01 µmol/ml) compared to the activity of Catalase and TAO concentration in serum for the control group (53.11±0.50 U/L, 1.261 ± 0.02 µmol/ml) respectively. Potassium, iron, and copper concentrations in the serum of the heart patients group were significantly higher than those in the serum of the control group (4.07 0.06 mmol/l, 122.45 0.95 g/dl, and 103.95 1.46 g/dl, respectively). Zinc concentration was also significantly lower in the serum of the heart patients group (73.48 2.08 g/dl) than in the control group. Although there was no discernible difference in the serum calcium concentration between the cardiac patient's group (8.53 0.08 mg/dl) and the control group (8.545 0.06 m/dl). Finally, the findings in the group of individuals with heart disease demonstrated a substantial negative correlation between the activity of serum CK-MB and serum calcium levels. It was also found that there was a substantial negative correlation between the serum CK-MB activity and the serum peroxidase and TAO concentrations, and a significant positive correlation between the serum catalase and iron concentrations